Iridium-Schiff base complex-based fluorimetric turn-off sensor and HPLC-DAD analytical approaches for quantitation of 8-hydroxy-2'-deoxyguanosine as an oxidative DNA damage biomarker in biofluids of healthy and diabetic subjects.

Hazim M Ali, Tamer H A Hasanin, Ahmed Hamad Alanazi, Emad Manni, Moamen S Refat, Azza H Rageh, Mohammed Gamal

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Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Hazim M AliDepartment of Chemistry, College of Science, Jouf University P.O. Box 2014 Sakaka Aljouf Saudi Arabia hmali@ju.edu.sa.ORCID https://orcid.org/0000-0003-0781-0850

Tamer H A HasaninDepartment of Chemistry, College of Science, Jouf University P.O. Box 2014 Sakaka Aljouf Saudi Arabia hmali@ju.edu.sa.

Ahmed Hamad AlanaziDepartment of Chemistry, College of Science, Jouf University P.O. Box 2014 Sakaka Aljouf Saudi Arabia hmali@ju.edu.sa.

Emad ManniDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University Saudi Arabia.

Moamen S RefatDepartment of Chemistry, College of Science, Taif University P.O. Box 11099 Taif 21944 Saudi Arabia.

Azza H RagehDepartment of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University Al-Madinah Al-Munawarah 30001 Saudi Arabia.

Mohammed GamalDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Beni-Suef University Alshaheed Shehata Ahmed Hegazy St. Beni-Suef 62574 Egypt mgamalm3000@yahoo.com.ORCID https://orcid.org/0000-0002-4674-6516

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a well-established biomarker of oxidative DNA damage formed through reactive oxygen species-mediated oxidation of guanosine residues. It is widely recognized as a laboratory biomarker of oxidative DNA damage and has been associated with carcinogenic progression. In this study, a novel, rapid, and highly selective spectrofluorometric platform was developed based on quenching of the fluorescence of a newly synthesized iridium-Schiff base complex by 8-OHdG; an HPLC-DAD method was also developed for confirmatory quantification. The iridium-Schiff complex exhibited intrinsic green fluorescence at

Identifiers

PMID42232191

DOI10.1039/d6ra02144a

PMCPMC13223893

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