Evidence map›Paper›PMID 42232181›Full record

ReviewFrontiers in pharmacology2026

The biology, function, and applications of exosomes as novel biomarkers for

Yihui Yang, Zhujun Yu, Wei Dou, Shuping Shi, Bo Zhang, Xin Liu

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yihui Yang *Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhujun Yu *Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Wei DouDepartment of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Shuping ShiDepartment of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Bo ZhangDepartment of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xin LiuDepartment of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes have become one of the hotspots in life science research in recent years. As an important carrier of bio-information substances, they can mediate intercellular communication by carrying various bioactive substances, thereby activating specific signal transduction pathways within cells and ultimately regulating cell phenotypes and functions. Among the abundant cargoes carried by exosomes, drug-metabolizing enzymes have gradually attracted increasing attention from researchers. More and more evidence suggests that the abundance and activity levels of these specific drug-metabolizing enzymes encapsulated in exosomes can often reflect the dynamic gene expression in their parent cells, which is of great significance for studying inter-individual variability in drug exposure. Based on this, this article reviews the biological origin of exosomes, related regulatory programs, their potential as biomarkers indicating

Indexed as

biomarkersdrug-metabolizing enzymesexosomesin vivo drug exposure variabilitytherapeutic drug monitoring

Identifiers

PMID42232181
PMCPMC13223083

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.