ReviewFrontiers in neurology
Decoding ferroptosis in intracerebral hemorrhage: multidimensional monitoring and integrative perspectives beyond single biomarkers.
Review in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
3 authors.
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Abstract
Although ferroptosis is well-established as a key driver of secondary brain injury following intracerebral hemorrhage (ICH), current monitoring strategies fail to capture its dynamic substrate-execution-amplification network. This failure stems from the susceptibility of single biomarkers to systemic inflammatory confounding and the lack of molecular sensitivity in conventional imaging, ultimately causing a profound disconnect between pathological monitoring and clinical intervention. In light of this, after critically evaluating existing limitations, this review proposes a mechanism-driven, multidimensional integrative monitoring framework: specifically, it aims to eliminate systemic confounding by combining iron metabolism with inflammatory indices (contextualization), track neuronal lipid peroxidation utilizing brain-derived exosomes and F4-neuroprostanes (specificity), and visualize iron deposition by integrating biofluid biomarkers with quantitative susceptibility mapping (spatial resolution). Such multimodal integration represents more than a mere refinement of diagnostic techniques; it is a prerequisite for achieving precision medicine in ICH. Serving as a critical companion diagnostic tool, this framework facilitates the stratification of patients responsive to iron chelation and anti-ferroptotic therapies, thereby propelling clinical management from empirical treatment toward mechanism-directed precision intervention.
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