ReviewMayo Clinic proceedings. Digital health2026
The Influence of Mobile Health Interventions on Aftercare and Medication Use for Patients With Chronic Pain: A Systematic Review.
Review in Mayo Clinic proceedings. Digital health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate the impact of mobile health interventions (MHIs) on opioid use, nonopioid medication use, adherence, quality-adjusted life years (QALYs), and health care utilization among adults with chronic pain. Patients and Methods: A systematic review (PROSPERO CRD4202457819) was conducted using PubMed, Embase, CINAHL, Web of Science, and the Cochrane Library from April 23, 2024, to May 2, 2025. Randomized controlled trials (RCTs) evaluating mobile-accessible interventions for adults aged 18-65 years with chronic pain, low back pain, or chronic low back pain were included. Two reviewers independently screened studies and assessed risk of bias. Owing to heterogeneity, outcomes were synthesized narratively, and standardized mean differences were calculated when appropriate. Results: Fourteen trials (n=3766) met inclusion criteria. Six studies (n=1098) evaluated opioid use, with 4 reporting significant reductions. All 5 studies assessing nonopioid medication use (n=810) demonstrated decreases. Of 4 studies examining adherence (n=851), 3 showed improvement. QALY gains were observed in 4 of 5 studies (n=2252), although effect sizes were small. No significant reductions in health care utilization were identified across included trials. Conclusion: Mobile health interventions reduce opioid and nonopioid medication use and improve adherence in adults with chronic pain. Evidence for QALY improvement is modest, and effects on health care utilization remain uncertain. Moreover, MHIs serve as valuable adjuncts to chronic pain care, particularly for medication stewardship. Further high-quality, long-term randomized trials using standardized outcome measures are needed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.