ArticleTetrahedron letters2025
Bioinspired synthesis of a lactam analogue of abyssomicin C.
Article in Tetrahedron letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
The bioinspired approach to abyssomicin C developed by Sorensen has been utilized to prepare a novel analog containing an α, β-unsaturated lactam. This synthesis was designed to utilize the intramolecular Diels-Alder reaction in late-stage synthesis to provide analogs that contain deep-seated modifications to explore their antimicrobial properties. Overall, installing this non-natural lactam moiety was successful and allowed for antimicrobial assessment of the analog, but the low yields highlight the frequent challenges of leveraging a bioinspired approach for a new-to-nature molecular target.
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