ArticleChem & bio engineering2026
Enhancing Diastereoselectivity of l‑Threonine Aldolase by Strengthening Kinetic Control To Mitigate Thermodynamic Equilibrium.
Article in Chem & bio engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The reaction catalyzed by l-threonine aldolase (LTA) for the formation of β-hydroxy-α-amino acids is governed by both kinetic and thermodynamic control, causing the diastereoselectivity of LTA to gradually decrease as the reaction progresses. This hinders the enzyme's industrial application. To address this, we proposed a strategy to enhance kinetic control via substrate tunnel engineering, thereby mitigating the influence of thermodynamic equilibrium. We investigated hotspot amino acid residues in the substrate tunnel using the VR-3M mutant from
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