ArticleCureus2026
Immunoglobulin A (IgA)-Mediated Vasculitis as a Paraneoplastic Clue in Chronic Lymphocytic Leukemia: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Immunoglobulin A (IgA)-mediated vasculitis is a small-vessel vasculitis defined by IgA-dominant immune complex deposition. Although common in children, adult-onset cases are rare and may signal underlying malignancies. In this case report, we present a 60-year-old male with chronic lymphocytic leukemia (CLL) under observation for his painful purpura and non-healing leg ulcers, with a biopsy confirming IgA vasculitis. His course was further complicated by steroid-induced diabetes, poor wound healing, recurrent infections, and fatal respiratory failure. He remained steroid-dependent with recurrent ulcer flares on tapering and infections, including pneumonia and varicella-zoster. Flow cytometry revealed persistent clonal B-cell populations with stable lymphocyte counts, suggesting subclinical CLL-driven immune dysregulation. This case highlights adult-onset IgA vasculitis as a potential paraneoplastic clue of indolent CLL even in the absence of leukemia progression. It underscores the importance of early malignancy screening, coordinated multidisciplinary care, and early steroid-sparing therapy in adult vasculitis patients with atypical features.
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