ArticleCureus2026
Impact of Platelet-Rich Plasma on the Rate of Canine Retraction: A Split-Mouth Randomized Clinical Trial.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe main concern of patients undergoing orthodontic treatment is the prolonged duration of treatment. Various measures have been introduced in the field of orthodontics to accelerate tooth movement. Tooth acceleration can be carried out by pharmacological and surgical methods; among them, platelet-rich plasma (PRP) is a minimally used method that has beneficial effects on skin, bone, and musculature. To understand its effect on the rate of tooth movement, this study aims to evaluate the effect of PRP therapy on the retraction rate in a split-mouth study design. Materials and methods: A split-mouth study was conducted on 30 patients requiring bilateral extraction of upper first premolars. PRP was prepared and injected into the alveolar mucosa, distal to the canine on experimental sides, with the contralateral sides acting as a control side. Canine retraction was started on the same day of PRP injection. Retraction was started using NiTi closed coil springs on both sides. The amount of canine retraction was measured and compared between both sides on 0 day, 21 days, and 42 days.
resultsThe results showed the mean rate of canine retraction in group PRP was 5.66±0.51, 4.50±0.54, and 3.16±0.40, respectively, at 0 day, 21 days, and 42 days, with a statistically significant difference between the control group (p<0.001). Increased tooth movement was observed on the experimental side compared to the control group.
conclusionPRP injections are a minimally invasive procedure and a safe approach for accelerating canine retraction and reducing overall treatment time. PRP can be used as an adjunct for accelerating the orthodontic tooth movement.
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