Evidence map›Paper›PMID 42231962›Full record

ArticleiScience2026

Epigenomic regulation of neural crest differentiation in human-induced pluripotent stem cells.

Kyosuke Mukae, Maya Shindo, Tianyuan Shi, Ritsuko Onuki, Satoshi Yamashita, Naoko Hattori, Toshikazu Ushijima, Miki Ohira, Takehiko Kamijo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kyosuke MukaeResearch Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan.
Maya ShindoResearch Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan.
Tianyuan ShiResearch Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan.
Ritsuko OnukiResearch Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan.
Satoshi YamashitaDepartment of Life Engineering, Faculty of Engineering, Maebashi Institute of Technology, Maebashi, Gunma, Japan.
Naoko HattoriDepartment of Epigenomics, Institute for Advanced Life Sciences, Hoshi University, Tokyo, Japan.
Toshikazu UshijimaDepartment of Epigenomics, Institute for Advanced Life Sciences, Hoshi University, Tokyo, Japan.
Miki OhiraResearch Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan.
Takehiko KamijoResearch Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neural crest cells (NCCs) drive vertebrate development through lineage specific differentiation into diverse tissues. Cranial (cNCCs) and trunk NCCs (tNCCs) exhibit distinct developmental trajectories that require coordinated epigenomic regulation. Aberrant NCC differentiation is associated with diseases including tumors. Epigenetic mechanisms such as histone modifications and DNA methylation are crucial for regulating NCC differentiation. Here, we used a human induced pluripotent stem cell model to compare differentiation of cNCCs and tNCCs and define lineage specific mechanisms. Integrated transcriptome and DNA methylome analyses revealed that DNA demethylation upstream of

Indexed as

cellular neuroscienceomicsstem cells research

Identifiers

PMID42231962
PMCPMC13224019

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.