Evidence map›Paper›PMID 42231957›Full record

ArticleiScience2026

Carbon monoxide-producing probiotic

Omar P Vallejos, Guillermo Hoppe-Elsholz, Pablo Reyes-Bustos, Eduardo I Tognarelli, Yaneisi Vázquez, Alejandro Piña-Iturbe, Patricia Pereira-Sánchez, Lucas Vásquez-Herrera, Javiera P Bahamondes-Abrigo, Valentina A Vergara-Espinoza and 17 more

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Omar P VallejosMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Guillermo Hoppe-ElsholzMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Pablo Reyes-BustosMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Eduardo I TognarelliMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Yaneisi VázquezMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Alejandro Piña-IturbeMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Patricia Pereira-SánchezMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Lucas Vásquez-HerreraMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Javiera P Bahamondes-AbrigoMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Valentina A Vergara-EspinozaMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Francisco B QueroMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Sofía Campos-GajardoMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Javiera Sepúlveda-AlfaroMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
José Acevedo-LópezMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Isidora D SuazoMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Pedro H SilvaMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Esteban CaamañoMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Valentina ScaffMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Franco BassiMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Irenice Coronado-ArrázolaMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Felipe Melo-GonzálezMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Alejandra MatelunaMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Manuel Álvarez-LobosMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Aniela WozniakMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Alexis M KalergisMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Pablo A GonzálezMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Susan M BuenoMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent infections and inflammatory diseases remain major health challenges due to their prevalence and limited prophylactic and therapeutic options. Heme oxygenases (HOs) degrade heme into bioactive molecules, including carbon monoxide (CO), a traditionally toxic gas yet naturally produced in mammals to regulate inflammation. Here, we investigated whether bacterial CO production via bacterial heme oxygenase ChuS, present in commensal

Indexed as

microbiologymolecular biology

Identifiers

PMID42231957
PMCPMC13223998

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.