ArticleiScience2026
Red blood cell deformability as a mechanobiological marker of CFTR dysfunction in cystic fibrosis.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cystic fibrosis (CF) is a genetic disorder caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), a chloride channel that controls salt and fluid transport across membranes. While CFTR is mainly studied in epithelial tissues, it is also detectable in red blood cells (RBCs), with a reduced expression in individuals with CF. However, the impact of this reduction on RBC deformability remains unexplored. Here, we investigated RBC deformability in CF using osmotic gradient ektacytometry. We examined 70 subjects with CF or CFTR-related disorders and compared them with 46 healthy control subjects. Our findings identify significant and reproducible alterations in RBC deformability associated with CFTR dysfunction, partially restored in subjects receiving highly effective CFTR modulators. These results support RBC deformability as a functional phenotype of CFTR dysfunction with prognostic potential, encouraging further investigations into the role of RBC membrane channels in cellular mechanics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.