Evidence map›Paper›PMID 42231920›Full record

ArticleSynthetic and systems biotechnology2026

The acetylation mechanism and engineering strategy of isocitrate lyase for optimizing biosynthesis in

Ruoyu Jia, Jichao Wang, Ying Zhang, Mo Xian, Qingsheng Qi, Min Liu, Guang Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthetic and systems biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruoyu JiaState Key Laboratory of Microbial Technology, Shandong University, 266237, Qingdao, China.
Jichao WangState Key Laboratory of Microbial Technology, Shandong University, 266237, Qingdao, China.
Ying ZhangState Key Laboratory of Microbial Technology, Shandong University, 266237, Qingdao, China.
Mo XianCAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China.
Qingsheng QiState Key Laboratory of Microbial Technology, Shandong University, 266237, Qingdao, China.
Min LiuState Key Laboratory of Microbial Technology, Shandong University, 266237, Qingdao, China.
Guang ZhaoState Key Laboratory of Microbial Technology, Shandong University, 266237, Qingdao, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lysine acetylation is a widespread post-translational modification that fine-tunes cell physiology and metabolism. Yet its application in metabolic engineering remains underexplored. Here, we report that the key enzyme of the glyoxylate shunt, isocitrate lyase (AceA) in

Indexed as

Enzyme activityGlyoxylate shuntIsocitrate lyaseLysine acetylationProtein stability

Identifiers

PMID42231920
PMCPMC13224001

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.