ArticleBeilstein journal of organic chemistry2026
Synthesis and structural elucidation of a novel bis-spirooxindole from isatin and ethylenediamine.
Article in Beilstein journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The reactivity of isatin toward ethylenediamine displays an unexpected stoichiometric divergence, affording either the anticipated diiminoisatin or a previously unreported pentacyclic bis-spirooxindole. A 2:1 isatin-to-diamine ratio provides the diiminoisatin, whereas a 1:2 ratio leads to the formation of a highly symmetric bis-spirooxindole scaffold. The new spirocyclic product was fully characterized by HRMS, IR and extensive 1D/2D NMR analysis, and its structure was unequivocally established by single-crystal X-ray diffraction. In addition, the isolated diiminoisatin can be independently reduced to the same bis-spirooxindole. These results broaden the scope of isatin-diamine condensations and demonstrate their potential to generate structurally complex spirooxindole architectures under simple conditions.
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