ArticleCurrent developments in nutrition2026
A Diverse Fiber Mixture, Reflective of a Nutritionally Balanced Diet, Is Well Tolerated by Healthy Adults.
Article in Current developments in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06115057 (The Investigation of Gastrointestinal Tolerance of a Novel Fibre Blend Among ≥45-<70-year-old Men and Women), which is not on this map. Not yet cited in PubMed.
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The Investigation of Gastrointestinal Tolerance of a Novel Fibre Blend Among ≥45-<70-year-old Men and Women
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10 authors.
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Abstract
Background: Adequate fiber intake is associated with health benefits and reduced disease risk. It is hypothesized that consuming a mixture of fiber types with distinct (physico)chemical characteristics, reflective of those naturally present in a nutritionally balanced diet, may help bridge the known "fiber gap" in many populations. However, good gastrointestinal (GI) tolerance of such a mixture of fiber types is essential to reach adequate fiber intake. Objectives: To evaluate GI tolerance of a diverse fiber mixture in healthy adults. Methods: In an open-label, single-arm, single-center study, healthy adults (45‒69 y) consumed 6 g/d of a diverse fiber mixture (FM) (2 × 3 g/d) for 4 wk alongside their habitual diet. FM comprised arabinoxylan, β-glucan, pectin, and resistant starch in proportions similar to those typically consumed in a nutritionally balanced diet. GI tolerance symptoms were assessed weekly using the Gastrointestinal Symptom Rating Scale (GSRS), along with fecal transit type and frequency, digestion-associated quality of life [Digestion Associated Quality of Life Questionnaire (DQLQ)], compliance, safety, and dietary intake. Results: Of 41 enrolled participants, 38 participants completed the study without major protocol deviations. Changes in GSRS dimensions remained below their respective minimal important differences, a measure of clinical relevance, except for the indigestion dimension from baseline to week 1, with a least-square mean and standard error of 0.4 ± 0.2, where the upper 95% confidence interval (0.0, 0.7) reached the minimal important differences of 0.7. GSRS scores remained otherwise stable over time. Weekly fecal frequency significantly increased from baseline to week 1 with least-square mean ± standard error of 1.4 ± 0.4 and 95% confidence interval (0.5, 2.3). No significant changes were observed in fecal frequency (week 4), fecal transit type, and the digestion-associated quality of life questionnaire. Conclusions: Daily consumption of 6 g FM for 4 wk was well tolerated by healthy adults.This trial was registered at clinicaltrials.gov as NCT06115057.
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