ArticleComputational and structural biotechnology journal2026
Phospholipids that Plug the Pores of Cholesteryl Ester Transfer Protein Control Its Triglyceride Transfer.
Article in Computational and structural biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cholesteryl ester transfer protein (CETP), a key drug target in cardiovascular disease, primarily regulates plasma circulating levels of lipids (within high, low, and very-low-density lipoproteins). In addition to its terminal openings, CETP has 2 additional openings, plugged by a phospholipid (PL) each. However, the mechanism, by which CETP moves lipids between lipoproteins, and roles of PL plugs in CETP function remain elusive. Further, small-molecule inhibitors targeting CETP tunnel displace PL during CETP inhibition. Here, using steered molecular dynamics simulations followed by
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