Evidence map›Paper›PMID 42231809›Full record

ArticleJournal of medicinal chemistry2026

Lead Optimization of TgCDPK1 Inhibitors for the Treatment of Toxoplasmosis.

Michael P Mannino, Anusha Gokanapalle, Shrushti Patil, Anoopjit Singh Kooner, Chhuttan Lal Meena, Matthew Medcalf, Igi Vilza, Jennifer Barks, Yong Fu, Jing Xia and 6 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Michael P ManninoDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0002-8135-1675
Anusha GokanapalleDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Shrushti PatilDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Anoopjit Singh KoonerDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0003-1747-5689
Chhuttan Lal MeenaDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0002-0535-1964
Matthew MedcalfDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Igi VilzaDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Jennifer BarksDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Yong FuDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0002-3912-5869
Jing XiaDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Jay C NixAdvanced Light Source, Lawrence Berkely National Laboratory, Berkeley California 94720, United States.
Chris NelsonDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Daved FremontDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Arun DhillonDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
L David SibleyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0001-7110-0285
James W JanetkaDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0002-9888-5411

Funding

Optimizing CDPK1 inhibitors for chronic toxoplasmosisR01AI164473 · NIAID · WASHINGTON UNIVERSITY · PI James W Janetka, L. David Sibley · 2022 to 2026
$3.9M
DESIGNING SELECTIVE INHIBITORS OF CALCIUM-DEPENDENT KINASES IN PARASITESR01AI094098 · NIAID · WASHINGTON UNIVERSITY · PI SIBLEY, L. DAVID · 2012 to 2015
$1.6M
NIAID NIH HHS R01 AI094098NIAID NIH HHS R01 AI164473
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Protein Kinase InhibitorsProtein KinasesPyrazolesPyrimidinesToxoplasmaToxoplasmosisAnimalsCrystallography, X-RayDrug DesignFemaleHumansMiceModels, MolecularStructure-Activity RelationshipProtein Kinase InhibitorsProtein KinasesPyrazolesPyrimidines

Identifiers

PMID42231809
PMCPMC13339196

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.