ArticleAngewandte Chemie (International ed. in English)2026
A Crystalline and Thermally Stable Selenocysteine Selenenic Acid.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Despite more than half a century of research on selenoproteins, the central catalytic intermediate, selenocysteine selenenic acid (Sec-SeOH), has remained experimentally elusive. Its isolation has long been impeded by its presumed instability and propensity for thermal deselenation. Here, we report the first isolable Sec-SeOH at ambient temperature. This relies on a bioinspired design of a selenopeptide sequence encapsulated within a protective cradle, together with an oxidant-free route from the corresponding selenenyl iodides (Sec-SeI), enabling x-ray structural analysis and chemical characterization. The isolated Sec-SeOH shows unexpected resistance to β-elimination to dehydroalanine (DHA). Oxidation experiments combined with theoretical calculations demonstrate that conversion to DHA proceeds preferentially via overoxidation to the seleninic acid (Sec-SeO
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