Evidence map›Paper›PMID 42231763›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2026

Immunoengineering External Field Responsive Biomaterials for Tissue Repair and Regeneration.

Wanli Song, Jia Song, Jinchu Liang, Yang Liu, Boon Chin Heng, Xuliang Deng, Xuehui Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wanli SongDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, P. R. China.ORCID https://orcid.org/0009-0008-3025-1376
Jia SongDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, P. R. China.
Jinchu LiangDepartment of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, P. R. China.
Yang LiuDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, P. R. China.
Boon Chin HengDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, P. R. China.
Xuliang DengDepartment of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, P. R. China.
Xuehui ZhangDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, P. R. China.ORCID https://orcid.org/0000-0003-1016-6488

Funding

Beijing Municipal Science & Technology Commission Z241100009024056Central Government Guidance Funding for Local Science and Technology Projects in Shanxi Province YDZJSX2024D075Hainan Provincial Natural Science Foundation of China 826ZD1024National Natural Science Foundation of China 52273258National Natural Science Foundation of China 52303171National Natural Science Foundation of China 82221003National Natural Science Foundation of China 82301076Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences 2023-PT320-09Sanjin Talent Program of Shanxi Province SJYC2025548Young Elite Scientists Sponsorship Programof the Beijing High Innovation Plan 20250810
6 · The paper itself

Abstract

Tissue defect repair is a dynamic process involving inflammation regulation, angiogenesis, organized extracellular matrix assembly, and immune microenvironment homeostasis. Its success critically depends on repair strategies with precise spatiotemporal control. External field-responsive biomaterials (EFRBs), which respond to optical, magnetic, electrical, ultrasonic, and thermal stimuli, have become a research focus in regenerative medicine due to their on-demand activation, unique (bio)physicochemical properties, and ability to modulate immune-related pathways. This review first outlines the dynamic biological requirements of tissue repair, including the immune microenvironment's role, and the core advantages of EFRBs. It then details the structural features and external field response mechanisms of various EFRBs-such as nanoparticles, scaffolds, hydrogels, and microneedles-and their regulatory effects on immune-related repair processes. Finally, it systematically summarizes recent advances in immunoengineering EFRBs for enhancing tissue repair and regeneration. This review thus aims to provide valuable insights for optimizing EFRB-based therapies and to inspire further breakthroughs in this evolving field.

Indexed as

Biocompatible MaterialsRegenerationTissue EngineeringWound HealingAnimalsHumansHydrogelsRegenerative MedicineTissue ScaffoldsBiocompatible MaterialsHydrogelsexternal fieldimmune regulationresponsive biomaterialstissue repair and regeneration

Identifiers

PMID42231763
PMCPMC13351775

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.