Reenvisioning the De Mayo Reaction: A Boron-Enabled Cycloaddition Approach.

Neetu Sharma, Yanyao Liu, Partha Sarathi Hazra, Evan B Piper, Ryan Van Hoveln, Michael Kevin Brown

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Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Neetu SharmaDepartment of Chemistry, Indiana University, Bloomington, Indiana, USA.

Yanyao LiuDepartment of Chemistry, Indiana University, Bloomington, Indiana, USA.

Partha Sarathi HazraDepartment of Chemistry, Indiana University, Bloomington, Indiana, USA.

Evan B PiperDepartment of Chemistry, Indiana University, Bloomington, Indiana, USA.

Ryan Van HovelnDepartment of Chemistry and Physics, Indiana State University, Terre Haute, Indiana, USA.

Michael Kevin BrownDepartment of Chemistry, Indiana University, Bloomington, Indiana, USA.ORCID https://orcid.org/0000-0002-4993-0917

Funding

Methods and Strategies for Chemical SynthesisR35GM131755 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Michael Kevin Brown · 2019 to 2026

$4.0M

Indiana UniversityNIGMS NIH HHS R35 GM131755NIH HHS R35GM131755

6 · The paper itself

Abstract

The De Mayo reaction is an established process in chemical synthesis for the synthesis of 1,5-dicarbonyls or cyclobutanols in selected cases. Herein, we present a reevisioned approach that utilizes alkenylboronates as surrogates for 1,3-dicarbonyls. The process allows for delayed controlled synthesis of the traditional De Mayo products. Elaboration of the C─B bond in the product was also demonstrated. A key aspect of the study is the identification of a rigid oxy-boracycle as a key intermediate to allow for bimolecular cycloaddition to occur. Mechanistic experiments are provided to clarify the importance of the chelate.

Indexed as

conformational lockcycloadditionDe Mayoenergy transferphotochemistry

Identifiers

PMID42231713

DOI10.1002/anie.202525317

PMCPMC13360748

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.