Evidence map›Paper›PMID 42231672›Full record

ReviewJournal of immunology research2026

IL-27: A Double-Edged Sword in Immune Regulation via JAK-STAT Orchestration.

Xiangqi Zhang, Chen Feng, Ye Xu, Yingqi Zeng, Qiulin Luo, Jiajie Qin, Tengfang Li, Longkai Peng, Hedong Zhang, Helong Dai

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiangqi ZhangDepartment of Immunology, School of Basic Medical Science, Central South University, Changsha, Hunan, China, csu.edu.cn.ORCID https://orcid.org/0009-0005-7793-1561
Chen FengDepartment of Kidney Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China, csu.edu.cn.ORCID https://orcid.org/0009-0001-5499-8692
Ye XuMedical College of Guangxi University, Nanning, Guangxi, China, gxtcm.com.ORCID https://orcid.org/0009-0006-9364-595X
Yingqi ZengDepartment of Kidney Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China, csu.edu.cn.ORCID https://orcid.org/0009-0009-2319-3742
Qiulin LuoDepartment of Immunology, School of Basic Medical Science, Central South University, Changsha, Hunan, China, csu.edu.cn.ORCID https://orcid.org/0009-0006-1848-3866
Jiajie QinDepartment of Kidney Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China, csu.edu.cn.ORCID https://orcid.org/0009-0000-4043-7619
Tengfang LiDepartment of Kidney Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China, csu.edu.cn.ORCID https://orcid.org/0000-0001-6345-6716
Longkai PengDepartment of Kidney Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China, csu.edu.cn.ORCID https://orcid.org/0000-0002-3189-6511
Hedong ZhangDepartment of Kidney Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China, csu.edu.cn.ORCID https://orcid.org/0000-0001-7924-5067
Helong DaiDepartment of Kidney Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China, csu.edu.cn.ORCID https://orcid.org/0000-0002-0696-3081

Funding

National Natural Science Foundation of China 82200849National Natural Science Foundation of China 82270796National Natural Science Foundation of China 82370761National Natural Science Foundation of China 82470789National Science and Technology Major Project of China 2025ZD0552200Science and Technology Innovation Program of Hunan Province 2022RC3071Strategic Research and Consulting Project of Hunan Institute of Engineering Technology Development Strategy in China 2025WK006
6 · The paper itself

Abstract

Interleukin-27 (IL-27) is a multifunctional cytokine produced mainly by innate immune cells that regulates immune responses primarily through the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway. The role of IL-27 in immune regulation is complex and often paradoxical, with both pro-inflammatory and immunosuppressive functions described, depending on the specific immune context and cellular milieu. Here, we systematically discuss the dual regulatory roles of IL-27 in immune regulation, with a particular emphasis on its role in the JAK-STAT signaling pathway. We highlight the latest advancements in understanding the functional differences and molecular mechanisms of IL-27 in both adaptive and innate immune cells. We further elaborate on IL-27-mediated immune regulation through nonimmune cells. Understanding the multifaceted and context-dependent properties of IL-27 is essential for deciphering the precise role of IL-27 in health and disease and for developing targeted immunotherapies. This review systematically analyzes the "double-edged sword" mechanism of IL-27, providing a theoretical and translational basis for targeting the JAK-STAT pathway.

Indexed as

Interleukin-27InterleukinsJanus KinasesSTAT Transcription FactorsAdaptive ImmunityAnimalsHumansImmunity, InnateImmunomodulationSignal TransductionInterleukin-27InterleukinsJanus KinasesSTAT Transcription FactorsIL-27immune regulationinflammationthe JAK-STAT signaling pathway

Identifiers

PMID42231672
PMCPMC13239342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.