Evidence map›Paper›PMID 42231654›Full record

ArticleRenal failure2026

Post-transplant anemia as a persistent risk factor for graft dysfunction in kidney transplant recipients.

Makoto Tsujita, Yutaka Matsuoka, Kazuharu Uchida, Kunio Morozumi

Abstract read
In one paragraph

Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Makoto TsujitaDepartment of Nephrology, Tajimi Clinic, Gifu, Japan.
Yutaka MatsuokaDepartment of Kidney Disease Center, Masuko Kinen Byoin, Nagoya, Japan.
Kazuharu UchidaDepartment of Kidney Disease Center, Masuko Kinen Byoin, Nagoya, Japan.
Kunio MorozumiDepartment of Kidney Disease Center, Masuko Kinen Byoin, Nagoya, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-transplant anemia (PTA) is associated with adverse graft outcomes after kidney transplantation. However, it remains unclear whether persistent anemia despite erythropoiesis-stimulating agent (ESA) therapy is associated with long-term graft dysfunction in routine clinical practice.

methodsThis single-center retrospective study included 323 kidney transplant recipients followed at Masuko Kinen Hospital, Japan, from 2019 to 2021. The primary analysis used a linear mixed-effects model with repeated averaged estimated glomerular filtration rate (eGFRave) measurements over 2 years, treating hemoglobin (Hb) as a time-updated covariate. Supportive analyses evaluated 2-year change in eGFRave in the overall cohort and a propensity score-matched cohort.

resultsRecipients receiving ESA therapy had lower Hb levels and worse baseline kidney function than those not receiving ESA therapy. In the primary linear mixed-effects model, eGFRave declined over time (

conclusionPersistent PTA, rather than ESA use itself, was associated with graft function decline in kidney transplant recipients. Hb likely reflects underlying graft pathology, inflammation, or ESA resistance rather than being directly causal.

Indexed as

AnemiaKidney TransplantationAdultFemaleGlomerular Filtration RateHematinicsHemoglobinsHumansJapanMaleMiddle AgedPropensity ScoreRetrospective StudiesRisk FactorsHematinicsHemoglobinsgraft functionkidney transplantationPost-transplant anemia

Identifiers

PMID42231654
PMCPMC13235221

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.