ArticleCancer medicine2026
The hsa_circ_0070354/miR-4322/RAB3B Axis Facilitates the Carcinogenesis and Development of Non-Small Cell Lung Cancer (NSCLC).
Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCircular RNA (hsa_circ_0070354), also known as circPTPN13, was demonstrated in our previous study that it can be used as a biomarker for diagnosing non-small cell lung cancer (NSCLC). However, the mechanism of its role in the occurrence and development of NSCLC has not been investigated. METHODS AND
resultsThe cell functions of NSCLC cells are evaluated by transfecting with relevant mimics, inhibitors, or plasmids in cell lines. After knocking down hsa_circ_0070354, the expression of miR-4322 increased, and RAB3B decreased, and the expression changed inversely after overexpression of hsa_circ_0070354. Mechanically, hsa_circ_0070354 acts as a ceRNA to adsorb miR-4322 and modulate Ras-Related Protein Rab-3B (RAB3B) to facilitate the proliferation, migration, invasion, and EMT of NSCLC cells. MiR-4322 or RAB3B inhibition restored proliferation, migration, and invasion of NSCLC cells after silencing of hsa_circ_0070354. In addition, hsa_circ_0070354 knockdown suppressed tumor growth in vivo.
conclusionsCollectively, our study reveals a promotive role of hsa_circ_0070354 in tumor proliferation, invasion, and migration by regulating the miR-4322/RAB3B axis and highlights that targeting the axis is a promising strategy for the intervention of NSCLC progression.
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