ArticleMolecular therapy : the journal of the American Society of Gene Therapy2026
Spatiotemporal atlas of pro-inflammatory NF-κB and anti-inflammatory STAT6 signaling using reporter mice during mRNA vaccination.
Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Immunization engages a highly coordinated series of innate and adaptive immune responses across multiple anatomical sites, a complexity that has contributed to the predominantly empirical nature of vaccine development. To address this limitation, we developed and validated a STAT6 reporter mouse that enables dynamic whole-body imaging and ex vivo characterization of STAT6-mediated anti-inflammatory signaling. We then integrated this model with an established NF-κB reporter system to dissect the immune activation triggered by two lipid nanoparticle (LNP)-formulated mRNA vaccines differing in RNA chemistry (unmodified versus N
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