Evidence map›Paper›PMID 42231576›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2026

Nicotinamide riboside enhances adoptive T cell therapy by promoting memory differentiation and metabolic fitness.

Nengzhi Pang, Jinping He, Lei Pei, Ying Xiao, Yingying Gu, Cheng Zhi, Xuye Lai, Mingtao Chen, Qiyao Xiao, Xueqian Wu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nengzhi PangDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510275, China; Key Laboratory of Tropical Translational Medicine of Ministry of Education, International Collaborative Research Center for the Development and Utilization of Tropical Food for Special Medical Purpose, School of Public Health, Hainan Medical University, Haikou, Hainan 571199, China; Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan 571199, China.
Jinping HeRadiology Center, Guangzhou Key Laboratory for Research and Development of Nano-Biomedical Technology for Diagnosis and Therapy, Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumour Microenvironment, Central Laboratory, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510260, China; Department of Ultrasound, Guangdong Women and Children Hospital, Guangzhou, Guangdong 510000, China.
Lei PeiDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
Ying XiaoDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
Yingying GuDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
Cheng ZhiDepartment of Pathology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510260, China.
Xuye LaiDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
Mingtao ChenDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
Qiyao XiaoDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
Xueqian WuDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
Zhenfeng ZhangRadiology Center, Guangzhou Key Laboratory for Research and Development of Nano-Biomedical Technology for Diagnosis and Therapy, Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumour Microenvironment, Central Laboratory, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510260, China. Electronic address: zhangzhf@gzhmu.edu.cn.
Lili YangDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510275, China. Electronic address: yangll7@mail.sysu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enhancing the efficacy of adoptively transferred T cells is essential for successful immunotherapy. The cytotoxic activity of these T cells is closely related to their mitochondrial function, which plays a critical role in T cell differentiation. This study explored the potential of nicotinamide riboside (NR), known to enhance mitochondrial function, to improve the efficacy of adoptively transferred CD8

Indexed as

Carcinoma, HepatocellularCell DifferentiationImmunologic MemoryImmunotherapy, AdoptiveLiver NeoplasmsMemory T CellsNiacinamidePyridinium CompoundsAnimalsCD8-Positive T-LymphocytesCell Line, TumorForkhead Box Protein O1HumansMetabolic ReprogrammingMiceMitochondriaForkhead Box Protein O1Niacinamidenicotinamide-beta-ribosidePyridinium Compoundsadoptive T cell therapyanti-tumor capacityCD8(+) T cellcentral memory T cellHCChepatocellular carcinomanicotinamide riboside

Identifiers

PMID42231576
PMCPMC13464305

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.