Evidence map›Paper›PMID 42231567›Full record

ArticleBiomarkers in medicine2026

Early prognostic value of combined procalcitonin and interleukin-6 in sepsis: a retrospective cohort study.

Xuefang Xia, Qinglan Zhu, Fenglian Chen, Ailing Shen

Abstract read
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Article in Biomarkers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Xuefang XiaDepartment of Laboratory Medicine, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, Jiangsu, China.
Qinglan ZhuDepartment of Laboratory Medicine, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, Jiangsu, China.
Fenglian ChenDepartment of Laboratory Medicine, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, Jiangsu, China.
Ailing ShenDepartment of Laboratory Medicine, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo investigate the value of combined procalcitonin (PCT) and interleukin-6 (IL-6) assessment for early risk stratification in sepsis. PATIENTS AND

methodsThis retrospective cohort study enrolled 375 patients with sepsis stratified by the first Sequential Organ Failure Assessment (SOFA) score within 24 h of admission. Serum PCT and IL-6 levels were collected. Multivariable logistic regression, receiver operating characteristic analysis, internal validation, decision curve analysis, and dynamic biomarker analyses were performed.

resultsPCT and IL-6 levels increased progressively across risk strata and correlated positively with SOFA score (both

conclusionEarly PCT and IL-6 levels were associated with sepsis severity and adverse outcomes. Combined biomarker assessment may provide adjunctive value for early sepsis risk stratification when interpreted together with established clinical indicators.

Indexed as

Interleukin-6ProcalcitoninSepsisAgedBiomarkersC-Reactive ProteinFemaleHumansMaleMiddle AgedOrgan Dysfunction ScoresPrognosisRetrospective StudiesROC CurveBiomarkersC-Reactive ProteinIL6 protein, humanInterleukin-6Procalcitoninearly risk stratificationinterleukin-6procalcitoninprognosisSepsis

Identifiers

PMID42231567
PMCPMC13285567

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