Evidence map›Paper›PMID 42231422›Full record

ArticleJournal of translational medicine2026

Near infrared photo-bacterialflora modulation technology realized controlling periodontitis: modulation of disease-associated dysbiosis in oral microbiota using near infrared photo-antibacterial targeting therapy (NIR-PAT

Hiroshi Maruyama, Kazuhide Sato, Kiyoshi Sakai, Hirotoshi Yasui, Ryu Okada, Li Xinheng, Koji Umeda, Shofiqur Rahman, Van Sa Nguyen, Hideharu Hibi

Abstract read
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In one paragraph

Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hiroshi MaruyamaDepartment of Oral and Maxillofacial Surgery, Nagoya University Hospital, Nagoya, Aichi, Japan.
Kazuhide SatoAdvanced Analytical and Diagnostic Imaging Center (AADIC) / Medical Engineering Unit (MEU), Nagoya University Institute for Advanced Research, B3 Unit, Nagoya, Aichi, Japan. sato.kazuhide.k5@f.mail.nagoya-u.ac.jp.ORCID 0000-0003-3025-088X
Kiyoshi SakaiDepartment of Oral and Maxillofacial Surgery, Nagoya University Hospital, Nagoya, Aichi, Japan. sakai.kiyoshi.j0@f.mail.nagoya-u.ac.jp.
Hirotoshi YasuiAdvanced Analytical and Diagnostic Imaging Center (AADIC) / Medical Engineering Unit (MEU), Nagoya University Institute for Advanced Research, B3 Unit, Nagoya, Aichi, Japan.
Ryu OkadaAdvanced Analytical and Diagnostic Imaging Center (AADIC) / Medical Engineering Unit (MEU), Nagoya University Institute for Advanced Research, B3 Unit, Nagoya, Aichi, Japan.
Li XinhengDepartment of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Koji UmedaImmunology Research Institute in Gifu, EW Nutrition Japan, 839-7, Sano, Gifu-city, Gifu, 501-1101, Japan.
Shofiqur RahmanImmunology Research Institute in Gifu, EW Nutrition Japan, 839-7, Sano, Gifu-city, Gifu, 501-1101, Japan.
Van Sa NguyenImmunology Research Institute in Gifu, EW Nutrition Japan, 839-7, Sano, Gifu-city, Gifu, 501-1101, Japan.
Hideharu HibiDepartment of Oral and Maxillofacial Surgery, Nagoya University Hospital, Nagoya, Aichi, Japan.

Funding

Japan Science and Technology Corporation CREST JPMJCR19H2Japan Science and Technology Corporation JPMJFR2017,FORESTJSPS 18K15923JSPS 25K03451JSPS 25K22916The Chemo-Sero-Therapeutic Research Institute Research Grant from The Chemo-Sero-Therapeutic Research Institute
6 · The paper itself

Abstract

backgroundPeriodontitis is a complex polymicrobial disease driven by synergistic interactions within a dysbiotic oral community. Within this network, Porphyromonas gingivalis acts as a keystone pathogen that orchestrates the pathogenic transformation of the microbiota. Current broad-spectrum antimicrobials often disrupt the entire microbial ecosystem and release immunogenic lipopolysaccharides (LPS). We aimed to develop a targeted approach, Near-Infrared Photo-Antibacterial Targeting Therapy (NIR-PAT

methodsWe evaluated the binding and bactericidal mechanism of NIR-PAT

resultsIn vitro, NIR-PAT

conclusionsThis study suggests that NIR-PAT

Indexed as

Anti-Bacterial AgentsDysbiosisInfrared RaysMicrobiotaMouthPeriodontitisPhotochemotherapyAnimalsHumansLipopolysaccharidesPhotosensitizing AgentsPorphyromonas gingivalisAnti-Bacterial AgentsLipopolysaccharidesPhotosensitizing AgentsIgYIR700DxNear infrared photo-bacterialflora modulation (NIR-PBM) technologyNear infrared photoimmunotherapyNIR-PAT2PeriodontitisPhoto-antimicrobial therapiesPorphyromonas gingivalis

Identifiers

PMID42231422
PMCPMC13231693

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.