ArticleJournal of translational medicine2026
Chronic liver diseases aggravate radiation-induced intestinal injury through taurocholic acid dysregulation.
Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChronic liver diseases (CLDs) are pervasive health issue worldwide, whereas radiation-induced intestinal injury is a frequent and consequential complication of abdominopelvic radiotherapy. Although these two pathological states often coexist clinically, the effects of CLDs on the development and severity of enteric radiation damage remain poorly understood. Therefore, the aim of this study was to investigate the effects of CLDs on radiation-induced intestinal injury and to elucidate the underlying mechanisms involved.
methodsMouse models of CCl
resultsCLDs reshaped the intestinal cellular landscape and exacerbated radiation-induced intestinal syndrome through bile acid-mediated hepatoenteric signalling. Liver injury shifted the gut microbiota, enriching Lachnospiraceae and other taxa, which led to abnormal elevation of taurocholic acid (TCA) in serum. Under radiation exposure, TCA overload disrupted intestinal homeostasis through three synergistic mechanisms. First, TCA compromised intestinal stem cell vitality, lowering the self-renewal and regenerative properties of the irradiated small intestine. Second, TCA activated Notch signalling in stem cells, impeding the differentiation of irradiated intestinal progenitors towards the secretory lineage to disrupt the differentiation trajectory. Third, TCA accumulated in irradiated absorptive enterocytes, destroying mitochondrial membrane integrity and hastening intrinsic apoptosis, contributing to radiation-induced cell death. Potential therapeutic strategies, including liver-protective agents, microbiota-targeted interventions, and mitochondrial protective compounds, have been proposed to mitigate the worsening intestinal toxicity associated with CLDs comorbidity during radiotherapy.
conclusionsThis study offers a detailed mechanistic understanding of how dysregulation of hepato-enteric crosstalk negatively affects the sensitivity of the intestines to ionizing radiation and proposes potential therapeutic approaches to reduce intestinal complications in patients with concurrent chronic liver diseases who are undergoing irradiation.
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