Evidence map›Paper›PMID 42231384›Full record

ArticleEnvironmental health : a global access science source2026

Preconception and early-pregnancy exposure to ambient air pollution and trajectories of depressive symptoms during pregnancy.

Yuhong Hu, Tingyu Yang, Sandrah P Eckel, Xinci Chen, Zhongzheng Niu, Claudia M Toledo-Corral, Nathan Pavlovic, Fred Lurmann, Brendan Grubbs, Laila Al-Marayati and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health : a global access science source, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yuhong HuDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Tingyu YangDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Sandrah P EckelDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Xinci ChenDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Zhongzheng NiuDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Claudia M Toledo-CorralDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Nathan PavlovicSonoma Technology, Inc., Petaluma, CA, USA.
Fred LurmannSonoma Technology, Inc., Petaluma, CA, USA.
Brendan GrubbsDepartment of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Laila Al-MarayatiDepartment of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Erika GarciaDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Santiago MoralesDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Jill JohnstonDepartment of Environmental and Occupational Health, Joe C. Wen School of Population & Public Health, University of California, Irvine, Irvine, CA, USA.
Genevieve F DuntonDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Rima HabreDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Shohreh F FarzanDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Carrie BretonDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Theresa M BastainDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. bastain@wustl.edu.

Funding

Lifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory Health (LA DREAMERs)UH3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M, BRETON, CARRIE VAN DOREN · 2018 to 2022
$28.4M
Project 3: Maternal Exposure to Environmental Hazards and Psychosocial Stressors and Postpartum Allostatic LoadP50MD015705 · NIMHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRETON, CARRIE VAN DOREN · 2020 to 2024
$8.1M
Project 2: Environmental Exposures, Stress, and Maternal Pregnancy-Related Weight OutcomesP50ES026086 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M · 2015 to 2019
$3.7M
EPA P50MD015705National Institute for Minority Health and Health Disparities 83615801-0National Institutes of Health Office of the Director ECHO Program UH3OD023287NIEHS NIH HHS P50 ES026086NIEHS NIH HHS P50ES026086NIH HHS UH3 OD023287NIMHD NIH HHS P50 MD015705
6 · The paper itself

Abstract

backgroundPrenatal depression shows diverse patterns in severity and progression. While air pollution has been linked to depression risk, its impact on the course of prenatal depression remains understudied. The study objectives were to (1) identify distinct trajectories of depressive symptoms across pregnancy, and (2) to evaluate whether preconception and early-pregnancy air pollution exposure impacts membership in trajectory groups.

methodsThis study followed 542 predominantly low-income Hispanic/Latina participants in the MADRES cohort. We assessed depressive symptoms using the Center for Epidemiologic Studies-Depression (CES-D) scale at 1st, 2nd, and 3rd trimester visits. Daily residential concentrations of PM

resultsWe identified four distinct trajectories: moderate-to-high symptoms (7.4%), consistently-moderate symptoms (14.6%), moderate-to-low symptoms (34.7%), and consistently-low symptoms (43.4%). Higher proportions of Black mothers and those not cohabitating were found in the two highest symptom trajectories. Participants with an interquartile range higher early-pregnancy NO

conclusionEarly-pregnancy exposure to ambient air pollution is associated with increased risk of moderate-to-high depressive symptoms across pregnancy.

Indexed as

Air PollutantsAir PollutionDepressionMaternal ExposureAdultFemaleHispanic or LatinoHumansParticulate MatterPregnancyYoung AdultAir PollutantsParticulate MatterAir pollutionDepression trajectoryEarly pregnancyLatent growth mixture modelingPrenatal depression

Identifiers

PMID42231384
PMCPMC13455309

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.