ArticleHuman genomics2026
QuaDB: A streamlined web tool for identifier-based rapid prediction of putative quadruplex sequences.
Article in Human genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Polyamines are i-motif disruptors.Molecular therapy. Nucleic acids · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundNon-canonical DNA structures, such as G-Quadruplexes (G4s) and i-Motifs (iMs), are pivotal in gene regulation and cellular processes. However, current computational methods for identifying their genomic precursors, Putative G4 Sequences (PGS) and Putative iM Sequences (PIS), primarily rely on manual sequence retrieval and input, thus hindering large-scale analyses essential for deciphering their biological functions. To address this, we present QuaDB, a user-friendly web application designed for identifier-based, rapid prediction of Putative Quadruplex Sequences (PQS).
resultsQuaDB streamlines the analytical workflow by enabling real-time sequence retrieval from Ensembl and NCBI using gene identifiers, coupled with automated region-specific analysis across promoter, gene body, and 3' downstream regions. The tool employs a robust, biologically informed scoring model that accurately identifies and scores quadruplex structures, aligning with experimental validation through circular dichroism and thermal melting studies. This validation demonstrated a direct correlation between QuaDB scores and thermal stability.
conclusionWith its efficient processing and intuitive interface, QuaDB facilitates comprehensive, large-scale genomic investigations, complementing existing tools by offering a unique identifier-based retrieval and region-aware analytical pipeline for exploring the widespread biological significance of these intriguing DNA structures. The web application can be accessed through: quadb.iitd.ac.in.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.