SynthesisBMC psychiatry2026
Deciphering the shared genetic architecture between schizophrenia and suicide attempt: a statistical genomic study.
Synthesis in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundEvidence for reciprocal comorbidity of schizophrenia (SCZ) and suicide attempt (SA) has been discussed in recent years. However, little evidence is known regarding the shared genetic architecture between SCZ and SA. This study investigated the genetic correlation and causality between them.
methodsLeveraging the genome-wide association summary statistics from European ancestry, we qualified local and global genetic correlations between the two traits through Heritability Estimation from Summary Statistics (ρ-HESS) and Linkage Disequilibrium Score Regression (LDSC). Cross-trait meta-analyses, cross-phenotype association, and colocalization analyses were utilized to identify and validate novel risk loci. Bidirectional Mendelian randomization (MR) was used to investigate causality. Tissue-level SNP heritability enrichment was assessed through Stratified LDSC and Multi-marker Analysis of GenoMic Annotation (MAGMA).
resultsLDSC identified significant positive genetic correlation between SCZ and SA (r
conclusionsOur study suggests a shared genetic architecture between SCZ and SA, characterized by overlapping pleiotropic variants, tissue-specific expression, and functionally shared genes. These findings delineate previously underappreciated genetic overlaps between them and provide a framework for future mechanistic exploration and therapeutic target discovery. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.