Evidence map›Paper›PMID 42231226›Full record

ArticleBMC public health2026

Ambient particulate matters are associated with attenuation or reversal of positive association between Folate and cognitive function in Chinese older adults.

Ying Cao, Beibei Yin, Yuwen Huang, Chao Ma, Zhihan Wang, Lili Yao, Lu Gao, Ziwei Tian, Wenyuan Liu, Xianglong Liu and 4 more

Abstract read
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In one paragraph

Article in BMC public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ying Cao *School of Health Services Management, Anhui Medical University, Hefei, Anhui, 230032, China.
Beibei Yin *School of Health Services Management, Anhui Medical University, Hefei, Anhui, 230032, China.
Yuwen Huang *School of Health Services Management, Anhui Medical University, Hefei, Anhui, 230032, China.
Chao MaSchool of Health Services Management, Anhui Medical University, Hefei, Anhui, 230032, China.
Zhihan WangSchool of Health Services Management, Anhui Medical University, Hefei, Anhui, 230032, China.
Lili YaoSchool of Health Services Management, Anhui Medical University, Hefei, Anhui, 230032, China.
Lu GaoSchool of Health Services Management, Anhui Medical University, Hefei, Anhui, 230032, China.
Ziwei TianDepartment of Epidemiology and Health Statistics, Center for Big Data and Population Health of IHM,School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China.
Wenyuan LiuDepartment of Epidemiology and Health Statistics, Center for Big Data and Population Health of IHM,School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China.
Xianglong LiuDepartment of Epidemiology and Health Statistics, Center for Big Data and Population Health of IHM,School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China.
Fangbiao TaoFuyang Center for Disease Prevention and Control, Fuyang, Anhui, 236069, China.
Bing HuAnhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui, 230032, China.
Linsheng YangDepartment of Epidemiology and Health Statistics, Center for Big Data and Population Health of IHM,School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China. yanglinsheng@ahmu.edu.cn.
Guimei ChenSchool of Health Services Management, Anhui Medical University, Hefei, Anhui, 230032, China. chengm@ahmu.edu.cn.

Funding

the Anhui Natural Science Foundation 1808085QH252the Key Scientific Research Fund of the Anhui Provincial Education Department 2023AH050610the Research Funds of the Center for Big Data and Population Health of IHM JKS2022015
6 · The paper itself

Abstract

backgroundResearch on combined effects between ambient particulate matters (PMs) and Folate (FA) with respect to cognitive function remains limited. This study aimed to investigate whether long-term PMs exposure could modulate the association between FA and cognitive function in Chinese older adults.

methodsThe study was composed of 3,880 individuals aged 60 and above. The cognition of the subjects was assessed using the Montreal Cognitive Assessment - Basic Version (MoCA-B). Folate concentration was measured through laboratory serum analysis, and data on ambient particulate matter levels were acquired from the China High Air Pollutant (CHAP) monitoring network. A linear regression analysis was conducted to explore how FA and PMs interact to affect cognitive function, with stratified analysis based on thresholds identified using restricted cubic splines (RCS).

resultsBased on the results of the linear trend analysis, PMs exposure exhibited a negative with MoCA-B scores (all P

conclusionOur findings indicated that PM exposure were associated with an attenuated positive association between FA and cognitive function, and even a negative association.Therefore, further action must be taken to reduce the harm caused by air pollution to enhance the cognitive benefits of FA.

Indexed as

Air PollutantsCognitionEnvironmental ExposureFolic AcidParticulate MatterAgedAged, 80 and overChinaEast Asian PeopleFemaleHumansMaleMiddle AgedAir PollutantsFolic AcidParticulate MatterAmbient particulate mattersCognitive functionFolateOlder adults

Identifiers

PMID42231226
PMCPMC13637198

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