Evidence map›Paper›PMID 42231200›Full record

ArticleBMC pediatrics2026

Analysis of clinical characteristics and risk factors for severe EBV infection in children-a single-center retrospective cohort study.

Xifeng Tang, Ting Sun, Guangyao Zhu, Yiping Zhou, Yucai Zhang, Rongxin Chen, Yun Cui

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Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Xifeng TangDepartment of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, No. 355, Luding Road, Putuo District, 200333, Shanghai, China.
Ting SunDepartment of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, No. 355, Luding Road, Putuo District, 200333, Shanghai, China.
Guangyao ZhuDepartment of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, No. 355, Luding Road, Putuo District, 200333, Shanghai, China.
Yiping ZhouDepartment of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, No. 355, Luding Road, Putuo District, 200333, Shanghai, China.
Yucai ZhangDepartment of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, No. 355, Luding Road, Putuo District, 200333, Shanghai, China.
Rongxin ChenDepartment of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, No. 355, Luding Road, Putuo District, 200333, Shanghai, China. rosine_chen@sina.com.
Yun CuiDepartment of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, No. 355, Luding Road, Putuo District, 200333, Shanghai, China. cuiyun0815@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the clinical features and risk factors of severe Epstein-Barr virus (EBV) infection in children.

methodsA retrospective analysis of the medical records of 144 cases admitted to the PICU (Pediatric Intensive Care Unit) and pediatric general wards of Shanghai Children's Hospital from January 2019 to March 2024 for Epstein-Barr virus (EBV) infection was conducted. The cases were categorized into severe and IM (Infectious Mononucleosis) groups according to the presence or absence of organ dysfunction.

resultsThe children in the severe group exhibited elevated incidences of gastrointestinal symptoms, cervical lymph node enlargement, hepatomegaly, and gallbladder and bile duct involvement (P ≤ 0.05). The plasma EBV DNA copy number of children in the severe group was higher than that in the IM group. Additionally, hemoglobin levels, D-dimer levels, lymphocyte subsets, and cytokines IL (Interleukin)-10 and IFN (Interferon)-γ were statistically different between the two groups (all P ≤ 0.05). Independent risk factors for severe EBV infection were identified as hemoglobin, IFN-γ and D-dimer. The predicted AUC (Area Under Curve) for hemoglobin was 0.83, with a critical value of 11.1 g/dL (P = 0.02); for D-dimer, the AUC was 0.93, with a critical value of 2.4 mg/L (P = 0.04); and for IFN-γ, the AUC was 0.80, with a critical value of 243.7 pg/ml (P = 0.04).

conclusionThis study suggests that hemoglobin, IFN-γ and D-dimer may are risk factors for progression of EBV infection to severe disease.

Indexed as

Epstein-Barr Virus InfectionsInfectious MononucleosisChildChild, PreschoolChinaDNA, ViralFemaleFibrin Fibrinogen Degradation ProductsHemoglobinsHerpesvirus 4, HumanHumansInfantMaleRetrospective StudiesRisk FactorsSeverity of Illness IndexDNA, ViralFibrin Fibrinogen Degradation Productsfibrin fragment DHemoglobinsD-dimerEpstein-Barr virusHemoglobinIFN-γ

Identifiers

PMID42231200
PMCPMC13465827

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.