Trial reportBMC anesthesiology2026
Association of pectoral nerve (PECS) and Serratus Anterior Plane (SAP) blocks with intraoperative left internal mammary artery free blood flow and hemodynamic responses in patients undergoing coronary artery bypass grafting: a randomized controlled trial.
Trial report in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05907798 (Effect of Serratus Anterior Plan Block), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Serratus Anterior Plan Block (SAP) and Pectoralis (PECSI-II) Peripheral Blocks on Left Internal Mammarian Artery (LIMA) Blood Flow in Coronary Bypass Surgery
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUltrasound-guided pectoral nerve (PECS) and serratus anterior plane (SAP) blocks are increasingly used for perioperative analgesia in cardiac surgery. However, their effect on intraoperative physiological parameters, such as left internal mammary artery (LIMA) blood flow, remains unclear. This study aimed to evaluate the association of PECS and SAP blocks with intraoperative LIMA free blood flow and hemodynamic responses in patients undergoing coronary artery bypass grafting (CABG).
methodsIn this prospective, randomized controlled trial, 150 adult patients undergoing elective, isolated, on-pump CABG were allocated to three groups: control (no block), PECS block, or SAP block (n = 50 per group). Blocks were performed preoperatively under ultrasound guidance. LIMA free blood flow was measured intraoperatively after harvesting under standardized hemodynamic conditions and expressed as mL/min. Hemodynamic responses to surgical incision, intraoperative opioid requirements, and vasoactive drug use were also recorded.
resultsBaseline characteristics were comparable among groups. LIMA free blood flow was higher in the PECS and SAP groups compared with the control group (mean ± SD: 83.1 ± 23.8 and 92.5 ± 21.0 vs. 60.6 ± 20.0 mL/min, respectively; p < 0.001), with higher values observed in the SAP group compared with the PECS group (p < 0.01). Both block groups demonstrated significantly attenuated increases in mean arterial pressure and heart rate in response to surgical incision (p < 0.001 for all comparisons) and reduced rescue opioid requirements. Vasoactive drug use prior to LIMA flow measurement was comparable among groups.
conclusionsPECS and SAP blocks were associated with attenuated hemodynamic responses to surgical incision and higher measured LIMA free blood flow under standardized conditions in patients undergoing CABG. These findings suggest that chest wall regional anesthesia techniques may influence intraoperative physiological parameters beyond their established analgesic effects. However, this study does not demonstrate improved graft patency, myocardial perfusion, or clinical outcomes. Further studies are warranted to determine whether these intraoperative differences translate into clinically meaningful benefits.
trial registrationClinicalTrials.gov NCT05907798. Registered on 23 May 2023, before the initiation of patient recruitment at our institution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.