Evidence map›Paper›PMID 42231057›Full record

ArticleJournal of the science of food and agriculture2026

A probiotic shield: Lactobacillus acidophilus immobilized in bacterial cellulose for a more sustainable release process and improved viability.

Parisa Moradi Eshkafti, Somayeh Rahaiee, Dariush Gholami

Abstract readEvaluation Study
In one paragraph

Article in Journal of the science of food and agriculture, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Parisa Moradi EshkaftiDepartment of Microbial Biotechnology, Faculty of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran.
Somayeh RahaieeDepartment of Microbial Biotechnology, Faculty of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran.
Dariush GholamiDepartment of Microbial Biotechnology, Faculty of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran.

Funding

The authors would like to thank Amol University of Special Modern Technologies (Amol, Iran) for financial support to perform this research.
6 · The paper itself

Abstract

backgroundProbiotics, defined as live microorganisms that confer a health benefit on the host when administered in adequate amounts, often require protective strategies to ensure their viability in food products. Immobilization in biopolymeric matrices presents a promising approach for enhancing bacterial resilience. This study focused on the fabrication of bacterial cellulose films as a platform for immobilizing Lactobacillus acidophilus. The physicochemical properties of the immobilized probiotic were investigated using Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). The release profile and viability of the bacteria were also evaluated under simulated gastrointestinal environments (simulated gastric fluid and simulated intestinal fluid).

resultsThe FTIR spectra confirmed the presence of the probiotic bacteria in the cellulose film. The FE-SEM results showed that the probiotic film had a smooth structure with reduced pores. XRD analysis also revealed that immobilizing probiotics in the cellulose film changes its crystalline structure to an amorphous state. TGA demonstrated the composite film's thermal stability, with mass losses of approximately 20% and 70.33% at 200 and 600 °C, respectively. The in vitro release profile demonstrated that immobilization significantly improved bacterial survival in simulated environments, particularly in simulated intestinal fluid.

conclusionCollectively, these results indicate that the probiotic L. acidophilus was qualitatively incorporated in the cellulose film, and its survival rate was maintained during storage time. This suggests potential as an efficient carrier in the functional food and pharmaceutical industries. © 2026 Society of Chemical Industry.

Indexed as

Cells, ImmobilizedCelluloseLactobacillus acidophilusProbioticsMicrobial ViabilitySpectroscopy, Fourier Transform InfraredX-Ray DiffractionCellulosebacterial cellulose filmscell viabilityimmobilizingLactobacillus acidophilusprobiotics

Identifiers

PMID42231057
PMCPMC13442747

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.