Evidence map›Paper›PMID 42230966›Full record

ArticleMolecular psychiatry2026

Genetics of major depressive disorder in a homogeneous population with uniform phenotyping.

Floris Huider, Yuri Milaneschi, René Pool, Bernardo de A P C Maciel, Scott D Gordon, Jihee Han, M Liset Rietman, Almar A L Kok, Tessel E Galesloot, Brittany L Mitchell and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Symptom-specific genetics reveal heterogeneity within major depressive disorder.medRxiv : the preprint server for health sciences · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors.

Floris HuiderDepartment of Complex Trait Genetics, Vrije Universiteit Amsterdam, 1081, Amsterdam, The Netherlands. f.huider@vu.nl.ORCID http://orcid.org/0000-0001-7776-7988
Yuri MilaneschiAmsterdam Public Health Research Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3697-6617
René PoolAmsterdam Public Health Research Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-5579-0933
Bernardo de A P C MacielDepartment of Complex Trait Genetics, Vrije Universiteit Amsterdam, 1081, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-1285-8701
Scott D GordonBrain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID http://orcid.org/0000-0001-7623-328X
Jihee HanDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
M Liset RietmanCenter for Prevention, Lifestyle and Health, Dutch National Institute for Public Health and the Environment, 3721, Bilthoven, The Netherlands.ORCID http://orcid.org/0000-0002-1796-7037
Almar A L KokAmsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Tessel E GaleslootIQ Health Science Department, Radboud University Medical Center, 6525, Nijmegen, The Netherlands.
Brittany L MitchellBrain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID http://orcid.org/0000-0002-9050-1516
Leen M 't HartAmsterdam Public Health Research Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-4401-2938
Femke RuttersAmsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Marieke T BlomAmsterdam Public Health Research Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-8088-1105
Didi RhebergenAmsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Marjolein VisserAmsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Ingeborg A BrouwerAmsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Edith FeskensDivision of Human Nutrition and Health, Wageningen University & Research, 6700, Wageningen, The Netherlands.ORCID http://orcid.org/0000-0001-5819-2488
Catharina A HartmanDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, 9713, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-8094-8859
Albertine J OldehinkelDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, 9713, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-3925-3913
Mariska BotAmsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Eco J C de GeusAmsterdam Public Health Research Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-6022-2666
Lambertus A KiemeneyIQ Health Science Department, Radboud University Medical Center, 6525, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-2368-1326
Martijn HuismanAmsterdam Public Health Research Institute, Amsterdam, The Netherlands.
H Susan J PicavetCenter for Prevention, Lifestyle and Health, Dutch National Institute for Public Health and the Environment, 3721, Bilthoven, The Netherlands.
W M Monique VerschurenCenter for Prevention, Lifestyle and Health, Dutch National Institute for Public Health and the Environment, 3721, Bilthoven, The Netherlands.ORCID http://orcid.org/0000-0003-2134-4227
Nicholas G MartinBrain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Conor V DolanAmsterdam Public Health Research Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-2496-8492
Hanna M van LooDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, 9713, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-9282-8053
Brenda W J H PenninxAmsterdam Public Health Research Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-7779-9672
Jouke-Jan HottengaAmsterdam Public Health Research Institute, Amsterdam, The Netherlands. jhottenga@hbku.edu.qa.
Dorret I BoomsmaDepartment of Complex Trait Genetics, Vrije Universiteit Amsterdam, 1081, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7099-7972

Funding

NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8M
Integration of Genomics & Transcriptomics in Normal Twins & Major DepressionRC2MH089951 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2009 to 2010
$6.5M
Genomics of Developmental Trajectories in TwinsRC2MH089995 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUDZIAK, JAMES J. · 2009 to 2010
$3.8M
Collaborative Study of Genetics of Dizygotic TwinningR01HD042157 · NICHD · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI MONTGOMERY, GRANT W · 2002 to 2006
$2.0M
Major Depression: Stage 1 Genomewide Association in Population-Based SamplesR01MH081802 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2007 to 2007
$138k
EPA EP-C-15-001Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) 184.021.007Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) 184.033.111NICHD NIH HHS R01 HD042157NIMH NIH HHS R01 MH081802NIMH NIH HHS RC2 MH089951NIMH NIH HHS RC2 MH089995NIMH NIH HHS U24 MH068457
6 · The paper itself

Abstract

Harmonized phenotyping and diverse population-specific studies are crucial for advancing gene discovery in psychiatric genetics. We conducted a genome-wide association (GWAS) mega-analysis of DSM-defined lifetime major depressive disorder (MDD) in 64 941 participants (25.7% cases) from the Dutch BIObanks Netherlands Internet Collaboration (BIONIC) consortium. Liability-scale SNP-based heritability was 12.0% (SE = 1.4%) as estimated by LDSC (assuming a lifetime prevalence of 15%) and 26.6% (SE = 1.1%) when estimated by LDAK-REML on individual-level genotype data, indicating substantial common-variant signal in this clinically harmonized sample. The genetic correlation with the latest major depression GWAS from the Psychiatric Genomics Consortium (PGC-MD) was high (r

Indexed as

Major Depressive DisorderAdultFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedMultifactorial InheritanceNetherlandsPhenotypePolymorphism, Single Nucleotide

Identifiers

PMID42230966
PMCPMC13569458

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.