Evidence map›Paper›PMID 42230957›Full record

ArticleNature immunology2026

Distinct transcription factors control tissue adaptation and effector function in infant and adult memory T cells.

Peter A Szabo, Hanna M Levitin, Siddhi Nargund, Thomas J Connors, David Chen, Jenny Jin, Puspa Thapa, Rebecca Guyer, Daniel P Caron, Joshua I Gray and 6 more

Abstract read
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Peter A SzaboDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-1603-761X
Hanna M LevitinDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.
Siddhi NargundDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0009-0009-9943-0628
Thomas J ConnorsDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-0199-7733
David ChenDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-9710-1857
Jenny JinMedical Scientist Training Program, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-7568-5732
Puspa ThapaDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Rebecca GuyerDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Daniel P CaronDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-1500-8713
Joshua I GrayDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-2796-5470
Rei MatsumotoDepartment of Surgery, Columbia University Irving Medical Center, New York, NY, USA.
Masaru KubotaDepartment of Surgery, Columbia University Irving Medical Center, New York, NY, USA.
Maigan BruskoDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-4331-2202
Todd M BruskoDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0003-2878-9296
Donna L FarberDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA. df2396@cumc.columbia.edu.ORCID http://orcid.org/0000-0001-8236-9183
Peter A SimsDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA. pas2182@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-3921-4837

Funding

Transcriptomics and Repertoire ProfilingP01AI106697 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2013 to 2026
$31.3M
Viral Assays CoreU19AI128949 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber, Peter Alan Sims · 2017 to 2026
$26.4M
Medical Scientist Training ProgramT32GM145440 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEVEN L REINER · 2022 to 2026
$7.3M
Evolution of T cell immunity in blood and tissues over childhoodU01AI168634 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2022 to 2026
$4.1M
Columbia University Graduate Training Program in Microbiology and ImmunologyT32AI106711 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Nicholas Arpaia, Uttiya Basu · 2014 to 2026
$2.1M
Development of Localized T Cell Immunity in Pediatric Respiratory Tract InfectionK23AI141686 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CONNORS, THOMAS · 2019 to 2023
$973k
Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) N/ALeona M. and Harry B. Helmsley Charitable Trust (Helmsley Charitable Trust) N/ANIAID NIH HHS P01 AI106697NIAID NIH HHS U01 AI168634NIAID NIH HHS U19 AI128949U.S. Department of Health & Human Services | National Institutes of Health (NIH) AI106697U.S. Department of Health & Human Services | National Institutes of Health (NIH) AI128949U.S. Department of Health & Human Services | National Institutes of Health (NIH) AI168634U.S. Department of Health & Human Services | National Institutes of Health (NIH) K23AI141686U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32AI106711U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32GM145440
6 · The paper itself

Abstract

Early life is essential for establishing memory T cells, which rapidly populate mucosal sites during infancy, although these nascent memory T cells are less protective than their adult counterparts. Here we used single-cell RNA sequencing of resting and CD3+CD28 antibody-stimulated T cells from lymphoid and mucosal tissues of infant (2-9 months) and adult (40-63 years) organ donors to investigate age-dependent mechanisms for functional regulation of human memory T cells. Infant CCL5

Indexed as

Ikaros Transcription FactorImmunologic MemoryMemory T CellsTranscription FactorsAdultChemokine CCL5HumansInfantChemokine CCL5Ikaros Transcription FactorIKZF2 protein, humanTranscription Factors

Identifiers

PMID42230957
PMCPMC13310763

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.