Articlenpj biomedical innovations2026
Human colon organoid Transwell model for investigating epithelial growth and repair.
Article in npj biomedical innovations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Patient-Derived Organoids in Gastrointestinal Disease: Current Applications, Limitations, and Future Perspectives.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disruption of the intestinal epithelial barrier is a hallmark of Inflammatory Bowel Disease (IBD), yet mechanisms of epithelial repair remain poorly understood. We developed a scalable human colon organoid-derived model in a 96-well Transwell system that recapitulates the cellular diversity and barrier function of the native epithelium. Using this platform, we investigated how various growth factors and cytokines influence epithelial maturation and repair following simulated inflammatory damage. Our results demonstrate that restorative factors, particularly EGF and TGFα, significantly enhance barrier integrity by reducing cell death and supporting proliferation under both chronic and acute inflammatory conditions. We also showed direct protective effects of immunomodulatory cytokines IL-2 and IL-10 on epithelial cells. This robust model provides a powerful high-throughput tool for dissecting mechanisms of intestinal repair and screening potential therapeutics to promote mucosal healing in IBD.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.