Evidence map›Paper›PMID 42230797›Full record

ArticleOncogene2026

Noncoding SNP rs17728461 modulates lung cancer progression via interchromosomal regulation of RAB27A expression.

Yan Jin, Xiaoling Tian, Wenxu Liu, Bing Guo, Xinyue Lei, Xinhua Liu, Guoli Li, Xujing Liu, Zengtuan Xiao, Mengzhe Zhang and 4 more

Abstract read
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In one paragraph

Article in Oncogene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Yan Jin *Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department of Cell Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China.
Xiaoling Tian *Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department of Cell Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China.
Wenxu Liu *Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department of Cell Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China.
Bing Guo *Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department of Cell Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China.
Xinyue LeiDepartment of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Xinhua LiuZhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department of Cell Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China.
Guoli LiDepartment of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Xujing LiuDepartment of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Zengtuan XiaoDepartment of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Mengzhe ZhangDepartment of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Yuxin FanZhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department of Cell Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China.
Zhenfa ZhangDepartment of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Zhenyi MaZhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department of Cell Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China. 20220070@hznu.edu.cn.ORCID http://orcid.org/0000-0001-6962-2711
Zhe LiuZhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department of Cell Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China. zheliu@hznu.edu.cn.ORCID http://orcid.org/0000-0002-2536-4180

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82403034National Natural Science Foundation of China (National Science Foundation of China) 82573173National Natural Science Foundation of China (National Science Foundation of China) 82573216National Natural Science Foundation of China (National Science Foundation of China) U25A20109
6 · The paper itself

Abstract

Genome-wide association studies (GWASs) have revealed the lung cancer susceptibility-associated non-coding SNP rs17728461 C/G. In this study, we demonstrated that rs17728461 is also associated with lung cancer outcome. The risk G allele increases the proliferative index and motility of cancer cells and promotes cancer metastasis in vivo in a xenograft mouse model. Mechanistically, rs17728461-G establishes a physical interchromosomal interaction between the rs17728461-bearing DNA fragment and the RAB27A gene locus and thereby increases RAB27A expression and promotes subsequent exosome secretion. eQTL analysis and immunostaining revealed an association between rs17728461-G and increased RAB27A expression in human lung cancers. These findings reveal a noncoding SNP-mediated interchromosomal regulatory mechanism underlying lung cancer progression.

Indexed as

Gene Expression Regulation, NeoplasticLung NeoplasmsPolymorphism, Single Nucleotiderab27 GTP-Binding ProteinsAnimalsCell Line, TumorCell ProliferationDisease ProgressionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMiceQuantitative Trait LociRAB27A protein, humanrab27 GTP-Binding Proteins

Identifiers

PMID42230797

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.