ArticleScientific reports2026
CAST/EiJ and NOG mice as lethal animal models for a 2022 human isolate of monkeypox virus Clade IIb.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The monkeypox virus (MPXV) outbreak has caused more than 150,000 infections worldwide since May 2022. The strain MPXV-ROK-P1-2022, isolated from the first patient in South Korea, belongs to the B.1.1 lineage of Clade IIb. To assess whether CAST/EiJ and NOG mice are suitable models for MPXV Clade IIb infection, we experimentally infected these mice with MPXV-ROK-P1-2022 and monitored clinical symptoms and body weight. For polymerase chain reaction, plaque assay, and histopathology, blood, lung, liver, spleen, testis, and brain tissues were collected. The results showed dose dependent lethality, and the virus established a systemic infection, replicating in multiple organs. Viral replication and DNA levels were exceptionally high in the testes. CAST/EiJ mice exhibited enlarged spleens with lymphoid depletion and scattered cellular necrosis. In summary, intraperitoneal challenge with the MPXV-ROK-P1-2022 Clade IIb strain causes a lethal, systemic infection in CAST/EiJ and NOG mice. The pronounced viral tropism for the testes highlights their potential as a model for studying MPXV pathogenesis and organ tropism and evaluating vaccine efficacy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.