Presence and associations of retinal pigment epithelium and outer retinal atrophy: the Beijing eye study.

Jost B Jonas, Songhomitra Panda-Jonas, Jie Xu, Rahul A Jonas, Ya Xing Wang

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Jost B Jonas *Rothschild Foundation Hospital, Institut Français de Myopie, Paris, France.

Songhomitra Panda-Jonas *Rothschild Foundation Hospital, Institut Français de Myopie, Paris, France.

Jie XuBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital Medical University, Beijing, China.

Rahul A JonasDepartment of Ophthalmology, Faculty of Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany.

Ya Xing WangTsinghua Medicine, Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, 100084, China. yaxingwang@tsinghua.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The goal of the study was to assess the presence of an incomplete (iRORA) and complete (cRORA) retinal pigment epithelium (RPE) and outer retinal atrophy in a general population and explore their associations with other parameters. Participants of the population-based Beijing Eye Study with age-related macular degeneration (AMD), polypoidal choroidal vasculopathy (PCV) or those without retinal diseases, underwent optical coherence tomography of the macula. Among 5894 eyes, presence of iRORA and cRORA increased from 0/5117 (0%) and 0/5117 (0%) in the normal group and 0/457 (0%) and 0/457 (0%) in early AMD to 5/277 (1.8%;95%CI:0.3,3.3) and 0/277 (0%) in intermediate AMD, 6/6 (100%) and 6/6 (100%) in geographic atrophy, 0/2 (0%) and 2/2 (100%) in exudative AMD, and 10/30 (33.3%;95%CI:17.8,48.8) and 6/30 (25.0%;95%CI:12.0,38.0) in PCV, respectively. Higher iRORA presence was associated (multivariable analysis) with higher AMD stage (OR:54.7;95%CI:6.68,449;P < 0.001), higher PCV presence (OR:1.523 × 10

Indexed as

Macular DegenerationRetinal Pigment EpitheliumAgedAged, 80 and overAtrophyBeijingFemaleHumansMalePolypoidal Choroidal VasculopathyTomography, Optical CoherenceAge-related macular degenerationcRORAEllipsoid zoneExternal limiting membraneiRORARetinal pigment epitheliumRetinal pigment epithelium and outer retinal atrophy

Identifiers

PMID42230733

DOI10.1038/s41598-026-55175-8

PMCPMC13469432

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