Evidence map›Paper›PMID 42230732›Full record

ArticleScientific reports2026

Effects of vasopressin and antihyperkalemic treatments on hemodynamics, potassium concentration, and resuscitation success in a porcine hyperkalemic cardiac arrest model.

Wan Young Heo, Hyoung Youn Lee, Najmiddin Mamadjonov, Hussain Ahmad, Yeon Heo, Yong Hun Jung, Seok Jin Ryu, Byung Kook Lee, Kyung Woon Jeung

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Wan Young HeoDepartment of Emergency Medicine, Chonnam National University Hospital, 42 Jebong-ro, Donggu, Gwangju, Republic of Korea.
Hyoung Youn LeeTrauma Center, Chonnam National University Hospital, 42 Jebong-ro, Donggu, Gwangju, Republic of Korea.
Najmiddin MamadjonovDepartment of Medical Science, Chonnam National University Graduate School, 60 Baekseo-ro, Donggu, Gwangju, Republic of Korea.
Hussain AhmadDepartment of Medical Science, Chonnam National University Graduate School, 60 Baekseo-ro, Donggu, Gwangju, Republic of Korea.
Yeon HeoDepartment of Internal Medicine, Chonnam National University Hospital, 42 Jebong-ro, Donggu, Gwangju, Republic of Korea.
Yong Hun JungDepartment of Emergency Medicine, Chonnam National University Hospital, 42 Jebong-ro, Donggu, Gwangju, Republic of Korea.
Seok Jin RyuDepartment of Emergency Medicine, Chonnam National University Hospital, 42 Jebong-ro, Donggu, Gwangju, Republic of Korea.
Byung Kook LeeDepartment of Emergency Medicine, Chonnam National University Hospital, 42 Jebong-ro, Donggu, Gwangju, Republic of Korea.
Kyung Woon JeungDepartment of Emergency Medicine, Chonnam National University Hospital, 42 Jebong-ro, Donggu, Gwangju, Republic of Korea. neoneti@hanmail.net.

Funding

Chonnam National University Hospital Biomedical Research Institute BCRZ25044
6 · The paper itself

Abstract

Vasopressin may improve blood flow during cardiopulmonary resuscitation (CPR) in hyperkalemic cardiac arrest. This could enhance the delivery of antihyperkalemic treatments and improve potassium-lowering effects and resuscitation outcomes. We assessed the effects of vasopressin and epinephrine, with and without antihyperkalemic treatments, on hemodynamics, laboratory parameters, and return of spontaneous circulation (ROSC) in a porcine model of hyperkalemic cardiac arrest. After inducing hyperkalemic cardiac arrest with potassium administration, 40 pigs were randomized into four groups: (1) epinephrine + saline placebo, (2) epinephrine + antihyperkalemic treatments, (3) vasopressin + saline placebo, and (4) vasopressin + antihyperkalemic treatments. Vasopressin (P = 0.004) and antihyperkalemic treatments (P = 0.042) significantly improved coronary perfusion pressure (CoPP) during CPR compared to epinephrine and saline placebo, respectively. Neither showed differences in potassium concentration during CPR compared to their respective controls. There was no significant interaction between vasopressor type and antihyperkalemic treatments for CoPP or potassium levels. Vasopressin and antihyperkalemic treatments significantly increased the odds of ROSC compared to epinephrine and saline placebo, respectively (both P = 0.017), with the highest ROSC rate in the combined treatment group. In conclusion, vasopressin improved ROSC through superior CoPP compared to epinephrine, without enhancing the potassium-lowering effects of antihyperkalemic treatments.

Indexed as

Cardiopulmonary ResuscitationHeart ArrestHemodynamicsHyperkalemiaPotassiumVasopressinsAnimalsDisease Models, AnimalEpinephrineFemaleSwineEpinephrinePotassiumVasopressinsAntihyperkalemic agentsCardiopulmonary resuscitationHeart arrestHyperkalemiaVasopressin

Identifiers

PMID42230732
PMCPMC13470170

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.