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ArticleScientific reports2026

Beam-F3 error analysis and validation of Neurally-F3 equations using realistic head models.

Rosa Pàmies-Vilà, Laia Mallol-Bordas, Vicenç Pascual-Rubio, Albert Fabregat-Sanjuan

Abstract readValidation Study
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Rosa Pàmies-VilàDepartment of Mechanical Engineering, Institute for Research and Innovation in Health (IRIS), Universitat Politècnica de Catalunya - BarcelonaTech (UPC), Barcelona, Spain.ORCID http://orcid.org/0000-0002-3814-9199
Laia Mallol-BordasMechanical Engineering Department, Universitat Rovira i Virgili, Tarragona, Spain.
Vicenç Pascual-RubioDepartment of Clinical Neurophysiology, Hospital Universitari Sant Joan de Reus, Reus, Spain.ORCID http://orcid.org/0000-0002-3191-795X
Albert Fabregat-SanjuanMechanical Engineering Department, Universitat Rovira i Virgili, Tarragona, Spain. a.fabregat@urv.cat.ORCID http://orcid.org/0000-0002-2878-1369

Funding

Agència de Gestió d'Ajuts Universitaris i de Recerca SLT033/23/000062European Regional Development Fund DTS24/00069Instituto de Salud Carlos III DTS24/00069'la Caixa' Foundation LCF/TR/CC22/52500009
6 · The paper itself

Abstract

Accurate localization of the F3 point is critical for non-invasive brain stimulation, particularly in repetitive transcranial magnetic stimulation (rTMS) targeting the dorsolateral prefrontal cortex. The Beam-F3 heuristic is widely adopted due to its simplicity, yet its accuracy across realistic cranial variations has not been systematically assessed. Here, we evaluated Beam-F3 against the standard F3 location defined by the 10-20 International System using 250 realistic head models representing diverse anatomies. Beam-F3 produced significant errors, with mean deviations of 5.59 ± 1.23 mm in female models and 6.09 ± 1.52 mm in male models. The Adjusted Beam-F3 method performed worse, with mean errors of 8.12 ± 1.96 mm in females and 8.96 ± 2.16 mm in males. To address these limitations, we developed sex-specific multiple linear regression equations, termed Neurally-F3, which retain the measurable scalp-distance methodology of Beam-F3. Cross-validation confirmed robustness (R

Indexed as

HeadTranscranial Magnetic StimulationFemaleHumansMaleModels, AnatomicReproducibility of ResultsBeam-F3 methodDorsolateral prefrontal cortexF3 localizationNon-invasive brain stimulationRealistic head modelsrTMSSI 10–20

Identifiers

PMID42230705
PMCPMC13469109

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