Observational studyScientific reports2026
Fibroblast growth factor-23 as an early biomarker of ischemic acute kidney injury after partial nephrectomy: prospective observational study.
Observational study in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Partial nephrectomy (PN) is a clinical model for ischemic acute kidney injury (AKI), which occurs in up to 39% of cases and increases long-term morbidity and mortality. Given that Fibroblast Growth Factor-23 (FGF23) rises rapidly with kidney dysfunction, this study assessed whether intraoperative FGF23 elevation predicts ischemic AKI after PN. Twenty-seven PN patients and sixteen controls with non-ischemic surgical kidney injury were enrolled. Blood samples for FGF23 ELISA were collected at baseline, 1 h post-ischemia (PN) or at the first surgical access (controls), and at 24 and 72 h postoperatively. AKI was defined by KDIGO criteria. AKI occurred in 44.4% of partial nephrectomy (PN) patients. Only patients with PN who developed AKI showed a significant early rise in FGF23, averaging 18.6 ± 9.5 pg/mL (p < 0.0001) one hour post-ischemia. This early increase in FGF23 is predictive of AKI (AUC = 0.75; 95% CI: 0.56-0.95; P = 0.026). An optimal cut-off increase of 19.35 pg/mL offered 58.3% sensitivity and 93.3% specificity. Intraoperative FGF23 elevation predicts AKI after PN and may be an early marker of ischemic kidney injury. Validation in larger cohorts is required.
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