ArticleScientific reports2026
Green synthesis of ZnO nanoparticles using bioactive compounds from the Amycolatopsis roodepoortensis strain EA7 and their effects in the HT-29 cell line.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The biological synthesis of nanoparticles (NPs) has attracted because of their non-toxic abilities. We reported the synthesis of ZnO nanoparticles (ZnO NPs) via an extract of the Amycolatopsis roodepoortensis strain EA7. Their physical characteristics were investigated with XRD, FT-IR, SEM, TEM, DLS, EDX, and zeta potential analyses. The toxicity of nanoparticles (NPs) was investigated via antimicrobial and the MTT assays in the HT-29, HEK293, and HDF1BOM cell lines.The expression levels of genes related to apoptosis (ATM, ATR, CHK1, and CHK2), anti apoptose (MMP-9 and Bcl-2), cell death, and cell cycle distribution were determined in the HT-29 cell line. ZnO nanoparticles (ZnO NPs) exhibited stronger antibacterial efficacy against clinical and standard Staphylococcus aureus (250 and 125 μg/mL) than Pseudomonas aeruginosa (500 μg/mL) by the MIC assay. The anticancer effects of these nanoparticles (NPs) demonstrated a dose‒dependent relationship against HT-29, HEK-293, and HDF1BOM cell lines. The IC
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