Evidence map›Paper›PMID 42230618›Full record

ArticleNPJ Parkinson's disease2026

Deep learning for freezing of gait assessment using inertial measurement units: a multicentre validation study.

Po-Kai Yang, Juha Carlon, Maaike Goris, Emilie Klaver, Jorik Nonnekes, Richard J A van Wezel, Lisa Alcock, Alison J Yarnall, Lynn Rochester, Clint Hansen and 10 more

Abstract read
In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Po-Kai Yang *KU Leuven, Department of Electrical Engineering (ESAT), Leuven, Belgium. po-kai.yang@kuleuven.be.
Juha Carlon *KU Leuven, Department of Electrical Engineering (ESAT), Leuven, Belgium.
Maaike GorisKU Leuven, Department of Rehabilitation Sciences, Neurorehabilitation Research Group (eNRGy), Leuven, Belgium.
Emilie KlaverMedical Spectrum Twente, Department of Neurology and Clinical Neurophysiology, Enschede, The Netherlands.
Jorik NonnekesRadboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Department of Rehabilitation, Centre of Expertise for Parkinson and Movement Disorders, Nijmegen, The Netherlands.
Richard J A van WezelRadboud University, Donders Institute for Brain, Cognition and Behaviour, Department of Neurobiology, Nijmegen, The Netherlands.
Lisa AlcockNewcastle University, Translational and Clinical Research Institute, National Institute for Health and Care Research (NIHR) Newcastle Biomedical Research Centre (BRC), Faculty of Medical Sciences, Newcastle Upon Tyne, UK.
Alison J YarnallNewcastle University, Translational and Clinical Research Institute, National Institute for Health and Care Research (NIHR) Newcastle Biomedical Research Centre (BRC), Faculty of Medical Sciences, Newcastle Upon Tyne, UK.
Lynn RochesterNewcastle University, Translational and Clinical Research Institute, National Institute for Health and Care Research (NIHR) Newcastle Biomedical Research Centre (BRC), Faculty of Medical Sciences, Newcastle Upon Tyne, UK.
Clint HansenUniversity Medical Center Schleswig-Holstein Campus Kiel, Department of Neurology, Kiel, Germany.
Christian SchlenstedtUniversity Medical Center Schleswig-Holstein Campus Kiel, Department of Neurology, Kiel, Germany.
Walter MaetzlerUniversity Medical Center Schleswig-Holstein Campus Kiel, Department of Neurology, Kiel, Germany.
David BuzagloTel Aviv Sourasky Medical Center, Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv, Israel.
Marina BrozgolTel Aviv Sourasky Medical Center, Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv, Israel.
Jeffrey M HausdorffTel Aviv Sourasky Medical Center, Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv, Israel.
Alice NieuwboerKU Leuven, Department of Rehabilitation Sciences, Neurorehabilitation Research Group (eNRGy), Leuven, Belgium.
Moran GilatKU Leuven, Department of Rehabilitation Sciences, Neurorehabilitation Research Group (eNRGy), Leuven, Belgium.
Pieter Ginis *KU Leuven, Department of Rehabilitation Sciences, Neurorehabilitation Research Group (eNRGy), Leuven, Belgium.
Bart Vanrumste *KU Leuven, Department of Electrical Engineering (ESAT), Leuven, Belgium.
Benjamin Filtjens *Delft University of Technology, Department of Engineering Systems and Services (ESS), Delft, The Netherlands. b.filtjens@tudelft.nl.

Funding

Fonds Wetenschappelijk Onderzoek 1SHEK24NFonds Wetenschappelijk Onderzoek S001024N
6 · The paper itself

Abstract

Video annotation is the gold standard for assessing Freezing of Gait (FOG) in Parkinsonian disorders, but it is time-consuming. Deep learning (DL)-based assessment of FOG using inertial measurement units ameliorates this problem but poses challenges. Particularly, the large heterogeneity between patients and assessment methods potentially affects detection performance between independent cohorts. To evaluate heterogeneity effects, we developed a DL model on a local cohort (85 participants; 2043 trials) and validated it across six external cohorts (256 participants; 1058 trials). Model-expert agreement on the percentage-of-time-frozen was strong locally (ICC = 0.886 [0.79, 0.90]) but reduced in external cohorts (ICC = 0.562 ± 0.141). Fine-tuning the DL model with just 50 min of external cohort data improved the ICC to 0.732 ± 0.138, approaching the lower boundary of the inter-rater agreement between two clinical raters using video annotation (ICC = 0.73-0.99). Therefore, while unified standards are still being developed, we propose a human-in-the-loop workflow as an effective intermediary and present a proof-of-concept web-based platform for fine-tuning and expert review ( aidfog.be ).

Identifiers

PMID42230618
PMCPMC13530201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.