Evidence map›Paper›PMID 42230601›Full record

ArticleNature communications2026

Phytochrome B sets condensate number through graded nucleator states and seeding-site efficacy.

Juan Du, Jiangman He, Erik M Chen, Tingdan Deng, Shivani Talati, Darwin Chang, Theodore J Mikhail, Meng Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juan Du *Department of Botany and Plant Sciences, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.ORCID http://orcid.org/0000-0003-0192-6633
Jiangman He *Department of Botany and Plant Sciences, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.ORCID http://orcid.org/0000-0002-6535-1544
Erik M ChenDepartment of Botany and Plant Sciences, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.ORCID http://orcid.org/0009-0000-4145-3880
Tingdan DengDepartment of Botany and Plant Sciences, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.ORCID http://orcid.org/0009-0008-2262-4662
Shivani TalatiDepartment of Botany and Plant Sciences, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.
Darwin ChangDepartment of Botany and Plant Sciences, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.
Theodore J MikhailDepartment of Botany and Plant Sciences, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.
Meng ChenDepartment of Botany and Plant Sciences, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA. meng.chen@ucr.edu.ORCID http://orcid.org/0000-0003-0351-5897

Funding

Genetic Characterization of Phytochrome Nuclear Bodies in Plant Light SignalingR01GM087388 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI CHEN, MENG · 2010 to 2023
$5.8M
NIGMS NIH HHS R01 GM087388NSF | Directorate for Biological Sciences (BIO) MCB-2141560U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM087388
6 · The paper itself

Abstract

Photobodies (PBs) are phytochrome B (phyB)-organized nuclear condensates that nucleate at defined subnuclear seeding sites and decrease in number with warming. How cells set PB number-and, more broadly, condensate number-remains poorly understood. Here we show that phyB's output module (OPM) functions as a universal nucleator for all site-defined PB types, whereas the photosensory module (PSM) attenuates this activity, enabling environmental control. Consistently, missense substitutions in OPM genetically separate intrinsic nucleation potency from PSM-mediated regulation. Unexpectedly, the constitutively active phyB

Indexed as

ArabidopsisArabidopsis ProteinsCell NucleusPhytochrome BTemperatureArabidopsis ProteinsPHYB protein, ArabidopsisPhytochrome B

Identifiers

PMID42230601
PMCPMC13392045

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.