Evidence map›Paper›PMID 42230551›Full record

ArticleSignal transduction and targeted therapy2026

Single-cell identifies and validates human circulating Treg subtype/state Treg

Xuanqi Liu, Yifei Liu, Wanxin Duan, Jianming Weng, Hao Dai, Fangming Liu, Lingyan Wang, Mengjia Qian, Bijun Zhu, Shuyao Wu and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Signal transduction and targeted therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Xuanqi Liu *Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University Shanghai Medical College, Shanghai, China.
Yifei Liu *Clinical Center for Molecular Diagnosis and Therapy, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Wanxin Duan *Shanghai Institute of Clinical Bioinformatics, Zhongshan Hospital Institute of Clinical Biomedicine, Shanghai, China.
Jianming Weng *Department of Pathology, Zhangzhou Hospital of Fujian Medical University, Zhangzhou, China.
Hao Dai *State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.
Fangming LiuShanghai Institute of Clinical Bioinformatics, Zhongshan Hospital Institute of Clinical Biomedicine, Shanghai, China.
Lingyan WangShanghai Institute of Clinical Bioinformatics, Zhongshan Hospital Institute of Clinical Biomedicine, Shanghai, China.
Mengjia QianShanghai Institute of Clinical Bioinformatics, Zhongshan Hospital Institute of Clinical Biomedicine, Shanghai, China.
Bijun ZhuShanghai Institute of Clinical Bioinformatics, Zhongshan Hospital Institute of Clinical Biomedicine, Shanghai, China.
Shuyao WuShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Youqiong YeShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0001-8332-4710
Muhan YuanShanghai Institute of Clinical Bioinformatics, Zhongshan Hospital Institute of Clinical Biomedicine, Shanghai, China.
Shaojun HongDepartment of Pathology, Zhangzhou Hospital of Fujian Medical University, Zhangzhou, China.
Mingjie WangDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Yunfeng ChengShanghai Institute of Clinical Bioinformatics, Zhongshan Hospital Institute of Clinical Biomedicine, Shanghai, China. cheng.yunfeng@zs-hospital.sh.cn.
Tianxiang ChenDepartment of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. c.tianxiang@gmail.com.
Duojiao WuShanghai Institute of Clinical Bioinformatics, Zhongshan Hospital Institute of Clinical Biomedicine, Shanghai, China. wu.duojiao@zs-hospital.sh.cn.
Yuanlin SongDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University Shanghai Medical College, Shanghai, China. song.yuanlin@zs-hospital.sh.cn.
Xiangdong WangDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University Shanghai Medical College, Shanghai, China. xdwang@fuccb.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulatory T cells (Treg) play immunosuppressive roles in lung cancer and are key biomarkers in cancer immunology. Using scRNA-seq and stereo-seq, we aimed to identify a novel circulating Treg subtype in non-small cell lung cancer (NSCLC). We developed a regional overlap-expression rate (rOER) system with cell identity marker gene panels (ciMGPs) to quantify T cell subtype specificity across pre/post-operative blood, 31 diseases, and in 17 organs. A Treg subtype (Treg

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsT-Lymphocytes, RegulatoryAnimalsCTLA-4 AntigenForkhead Transcription FactorsGene Expression Regulation, NeoplasticHumansInterleukin-2 Receptor alpha SubunitMiceProto-Oncogene MasProto-Oncogene Protein c-ets-1Single-Cell AnalysisCTLA-4 AntigenCTLA4 protein, humanETS1 protein, humanForkhead Transcription FactorsFOXP3 protein, humanIL2RA protein, humanInterleukin-2 Receptor alpha SubunitMAS1 protein, humanProto-Oncogene MasProto-Oncogene Protein c-ets-1

Identifiers

PMID42230551
PMCPMC13230995

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.