Evidence map›Paper›PMID 42230506›Full record

ArticleBulletin of experimental biology and medicine2026

Antidepressant Activity of 11-Dialkylaminoethyl-2,3,4,5-tetrahydrodiazepino[1,2-a]benzimidazole Derivative DAB-21 in a Model of Chronic Unpredictable Mild Stress.

M O Maltseva, D V Maltsev, M V Miroshnikov, L A Smirnova, L N Divaeva, A S Morkovnik, A A Spasov

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Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

M O MaltsevaVolgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia. maria.maltseva.volsmu@mail.ru.
D V MaltsevVolgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
M V MiroshnikovVolgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
L A SmirnovaVolgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
L N DivaevaResearch Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia.
A S MorkovnikResearch Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia.
A A SpasovVolgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The antidepressant properties of DAB-21 a compound with anxiolytic activity, were studied in C57BL/6 mice after modeling chronic unpredictable mild stress. In the Porsolt swim and tail suspension tests, the effect of DAB-21 was similar to that of amitriptyline, imipramine, and fluoxetine. In the open field test, the substance did not stimulate the motor activity of animals, which excludes the pseudo-antidepressant effect. HPLC analysis of monoamines and their metabolites in the frontal cortex showed that the 5-HIAA/serotonin ratio in animals treated with DAB-21 was 0.1, which is closest to that in the fluoxetine group. These findings suggest that the anxiolytic and antidepressant effects of DAB-21 are mediated via the serotonergic pathway.

Indexed as

Anti-Anxiety AgentsAntidepressive AgentsBenzimidazolesDepressionStress, PsychologicalAmitriptylineAnimalsDisease Models, AnimalFluoxetineFrontal LobeHindlimb SuspensionHydroxyindoleacetic AcidImipramineMaleMiceMice, Inbred C57BLAmitriptylineAnti-Anxiety AgentsAntidepressive AgentsBenzimidazolesFluoxetineHydroxyindoleacetic AcidImipramineSerotoninchronic unpredictable mild stressDAB-21depressionHPLCopen field

Identifiers

PMID42230506

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.