Evidence map›Paper›PMID 42230488›Full record

ArticleBulletin of experimental biology and medicine2026

Association of Uterine Fibroids GWAS-Significant Loci rs11031731 THEM7P/WT1 and rs58415480 SYNE1 with the Risk of Obesity.

L A Gliantseva, K I Ragulina, T V Markina, V R Rukavitsyn, G A Lazareva, T A Denisyuk, I N Medvedeva, O Yu Bushueva

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Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

L A GliantsevaKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia. liubov.ponomareva07@gmail.com.
K I RagulinaKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
T V MarkinaKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
V R RukavitsynKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
G A LazarevaKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
T A DenisyukKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
I N MedvedevaKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
O Yu BushuevaKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uterine fibroids and obesity are comorbid conditions with similar pathogenetic mechanisms. The aim of this study was to analyze the association of GWAS-significant uterine fibroid loci with the risk of obesity. DNA genotyping of 115 obese and 218 non-obese patients for 17 SNPs was performed by real-time PCR. An association was established between rs58415480 SYNE1 (effect G allele; OR = 0.61; p = 0.019) and rs11031731 THEM7P/WT1 (effect A allele; OR = 0.63; p = 0.04) with a reduced risk of obesity. Bioinformatic analysis showed that the alleles modulate the binding sites of transcription factors that cause inhibition of adipogenesis, regulation of glucose and lipid metabolism, as well as the retinoic acid and Notch signaling pathways, which indicates the pleiotropic role of these loci and their involvement in both the proliferative and metabolic pathways.

Indexed as

LeiomyomaNerve Tissue ProteinsNuclear ProteinsObesityUterine NeoplasmsAdultAllelesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMiddle AgedPolymorphism, Single NucleotideSignal TransductionNerve Tissue ProteinsNuclear ProteinsGWASobesityrs11031731rs58415480uterine fibroids

Identifiers

PMID42230488

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.