Acquired hemophilia A following influenza vaccination: a case report and literature review.

Dorit Blickstein, Talia Filipovich-Rimon, Osnat Garach-Jehoshua, Maya Koren-Michowitz

Abstract readCase ReportsReview

In one paragraph

Review in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dorit BlicksteinDepartment of Hematology, Shamir Medical Center, Be'er Ya'akov, Israel.ORCID http://orcid.org/0000-0001-5693-1996

Talia Filipovich-RimonHematology Laboratory, Shamir Medical Center, Be'er Ya'akov, Israel.

Osnat Garach-JehoshuaHematology Laboratory, Shamir Medical Center, Be'er Ya'akov, Israel.

Maya Koren-MichowitzDepartment of Hematology, Shamir Medical Center, Be'er Ya'akov, Israel. korenm@shamir.gov.il.ORCID http://orcid.org/0000-0002-7223-328X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acquired hemophilia A (AHA) is a rare bleeding disorder caused by the development of autoantibodies against coagulation factor VIII. It is idiopathic in approximately 50% of cases, but is also reported in association with malignancies, autoimmune diseases, pregnancy, and medications. We describe an 81-year-old man who developed AHA after receiving an influenza vaccination. The patient was treated with hemostatic therapy and immunosuppressive agents, achieving complete clinical and laboratory remission. Although extremely rare, influenza vaccination may trigger the development of AHA and should be considered in the differential diagnosis of newly diagnosed cases without other identifiable causes.

Indexed as

Hemophilia AInfluenza VaccinesVaccinationAged, 80 and overAutoantibodiesFactor VIIIHumansImmunosuppressive AgentsMaleAutoantibodiesFactor VIIIImmunosuppressive AgentsInfluenza VaccinesAcquired hemophilia ABleedingFactor VIII inhibitorInfluenza vaccination

Identifiers

PMID42230413

DOI10.1007/s00277-026-07095-w

PMCPMC13447536

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